Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases.
Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases.
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DOI：
10.1186/s13578-021-00700-7
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发表时间：
2021-11-02
影响因子：
7.5
通讯作者：
Zheng H
中科院分区：
文献类型：
--
作者：
Du S;Zheng H
衰老发生在我们所有人的生活中。由于生活水平的提高和拯救生命药物的发现，在过去的世纪里，我们的预期寿命在全世界大幅度增加。然而，寿命的延长导致65岁及65岁以上人口的数量和百分比都出现前所未有的增长，同时，2型糖尿病和阿尔茨海默病等与年龄有关的疾病的发病率也在增加。FoxO转录因子是进化上保守的分子，在多种生物过程中发挥关键作用，特别是衰老和代谢。在许多与年龄相关的疾病的发病机制中经常发现它们的功能障碍。本文就FoxO蛋白的信号通路和细胞功能进行综述。我们还回顾了FoxO在衰老和年龄相关疾病中的复杂作用，重点关注2型糖尿病和阿尔茨海默病，并讨论了FoxO作为衰老和疾病风险之间分子联系的可能性。
Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has increased substantially across the world in the past century. However, the rise in lifespan leads to unprecedented increases in both the number and the percentage of individuals 65 years and older, accompanied by the increased incidences of age-related diseases such as type 2 diabetes mellitus and Alzheimer’s disease. FoxO transcription factors are evolutionarily conserved molecules that play critical roles in diverse biological processes, in particular aging and metabolism. Their dysfunction is often found in the pathogenesis of many age-related diseases. Here, we summarize the signaling pathways and cellular functions of FoxO proteins. We also review the complex role of FoxO in aging and age-related diseases, with focus on type 2 diabetes and Alzheimer’s disease and discuss the possibility of FoxO as a molecular link between aging and disease risks.
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影响因子：
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