Gastrointestinal motility disorders in patients with multiple sclerosis: A single-center study.
Gastrointestinal motility disorders in patients with multiple sclerosis: A single-center study.
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DOI：
10.1111/nmo.14326
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发表时间：
2022-08
影响因子：
3.5
通讯作者：
Camilleri, Michael
中科院分区：
文献类型：
--
作者：
Khanna, Lehar;Zeydan, Burcu;Kantarci, Orhun H.;Camilleri, Michael
多发性硬化症（MS）中最常见的胃肠道症状与下肠功能障碍有关，通常与膀胱症状相关。为了评估ms患者的临床和客观胃肠运动功能障碍，这是一项单中心、回顾性研究，对1996年至2020年间的166例患者进行了评估。我们回顾了多发性硬化症的特征、胃肠道和神经系统症状、胃肠道和结肠运输测量以及肛肠压力测量。在对166例MS患者（女性138例，83%）进行胃肠道评估时，111例处于复发缓解期，52例处于进展期。在3例患者中，由于数据不足，未分配疾病分期。82%（136/166）的患者存在便秘。多数[103/116(88%)]膀胱症状患者同时伴有便秘或大便失禁。在队列中，分别有16%和7%的人发现胃排空在4小时和结肠转运在24小时延迟；22%的患者胃排空加速。肛门直肠测压显示，静息肛门括约肌压bb0 - 90mmHg，直肠肛管压差低于- 50mmHg提示便秘患者存在排便障碍。除了结肠运输缓慢和肛肠功能障碍导致MS便秘外，22%的患者胃排空加速。对166例MS患者（女性138例，83%）进行胃肠道评估，111例为复发缓解期，52例为进行性，3例为不确定期：胃排空延迟和结肠转运分别占16%和7%；22%的人胃排空加速；6/33例便秘患者经肛肠测压证实有排便障碍
Most prevalent gastrointestinal symptoms in multiple sclerosis (MS) relate to lower bowel dysfunction, often in association with bladder manifestations. To assess clinical and objective gastrointestinal motor dysfunctions in patients with MS. This was a single-center, retrospective study of 166 patients evaluated between 1996 and 2020. We reviewed characterization of the MS, gastrointestinal and neurological symptoms, and measurements of gastrointestinal and colonic transit, and anorectal manometry. At the time of the gastrointestinal evaluations of the 166 patients with MS (138 females; 83%), 111 were in the relapsing-remitting phase and 52 were in the progressive phase. In 3 patients, disease phase was not assigned due to insufficient data. Constipation was identified in 82% (136/166) of patients. Most [103/116 (88%)] patients with bladder symptoms also had constipation or fecal incontinence. Delayed gastric emptying at 4h and colonic transit at 24h was identified in 16% and 7% of the cohort, respectively; 22% had accelerated gastric emptying. On anorectal manometry, resting anal sphincter pressure >90mmHg and rectoanal pressure differential below −50mmHg suggested evacuation disorder in patients with constipation. In addition to slow colonic transit and anorectal dysfunction leading to constipation in MS, 22% of patients had accelerated gastric emptying. Gastrointestinal evaluations of the 166 patients with MS (138 females; 83%), 111 relapsing-remitting phase, 52 progressive, 3 non-determined: Delayed gastric emptying and colonic transit in 16% and 7% respectively; 22% accelerated gastric emptying; 6/33 patients with constipation had defecatory disorder proven by anorectal manometry
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影响因子：
3.5
作者：
Kusunoki, H.;Haruma, K.;Tack, J.
通讯作者：
Tack, J.
DOI：
10.1152/ajpgi.00197.2017
发表时间：
2017-11-01
影响因子：
4.5
作者：
Jacob, Deepti;Busciglio, Irene;Camilleri, Michael
通讯作者：
Camilleri, Michael
影响因子：
3.5
作者：
Camilleri M;Iturrino J;Bharucha AE;Burton D;Shin A;Jeong ID;Zinsmeister AR
通讯作者：
Zinsmeister AR
影响因子：
3.5
作者：
Oblizajek, Nicholas R.;Gandhi, Sangeetha;Bharucha, Adil E.
通讯作者：
Bharucha, Adil E.
影响因子：
3.5
作者：
Breen M;Camilleri M;Burton D;Zinsmeister AR
通讯作者：
Zinsmeister AR