Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants.
Performance characteristics of scintigraphic measurement of gastric emptying of solids in healthy participants.
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DOI：
10.1111/j.1365-2982.2012.01972.x
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发表时间：
2012-12
影响因子：
3.5
通讯作者：
Zinsmeister AR
中科院分区：
文献类型：
--
作者：
Camilleri M;Iturrino J;Bharucha AE;Burton D;Shin A;Jeong ID;Zinsmeister AR
胃排空（GE）在药效学和诊断研究中测量。评估健康受试者科学测量GE的受试者间和受试者内变异系数（COV），以及GE与性别和BMI的关系。数据从参与者与闪烁测量胃排空固体进行了分析。主要终点是胃排空T1/2 （get1 /2）和1、2、3和4小时的胃排空GE。患者队列包括105名男性和214名女性；至少在47名受试者中进行了2项研究[16名男性(M)， 32名女性(F)]。GE T1/2的受试者间COV （COVinter）在M和F中相似：总体为24.5% (M 26.0%, F 22.5%)；可预测的是，GE的COV在4小时时最低（COVinter为9.6%）。T1/2和GE4h的COVinter值总体为23.8%和12.6%，与COVinter值相似。性别（不包括年龄和体重指数[BMI]）与GE T1/2显著相关[p<0.001, F 127.6±28.7 (SD) min；M（109.9±28.6 min）和GE （1h和2h）。47名受试者的重复GE T1/2值显著相关（r= 0.459, p<0.001），中位差异为- 6分钟（平均- 1.6，范围- 56至72分钟）。Bland-Altman图显示Δ GE T1/2在平均GE T1/2 100-155分钟和间隔90 - 600天的研究中分布相似。受试者间扫描GE结果的差异仅略高于受试者内部测量值，这在健康志愿者中也可随时间重复。性别，而不是身体质量指数，与GE结果显著相关。
Gastric emptying (GE) is measured in pharmacodynamic and diagnostic studies. To assess inter- and intra-subject coefficients of variation (COV) of scintigraphic GE measurements in healthy subjects, and associations of GE with gender and BMI. Data from participants with scintigraphic measurements of gastric emptying of solids were analyzed. Primary endpoints were gastric emptying T1/2 (GE T1/2) and GE at 1, 2, 3 and 4 hours. The patient cohort consisted of 105 males and 214 females; at least 2 studies were performed in 47 subjects [16 males (M), 32 females (F)]. Inter-subject COV (COVinter) for GE T1/2 were similar in M and F: overall 24.5% (M 26.0%, F 22.5%); COV are predictably lowest for GE at 4h (COVinter 9.6%). COVintra for T1/2 and GE4h were overall 23.8% and 12.6%, and were similar to COVinter values. Gender (but not age or body mass index [BMI]) was significantly associated with GE T1/2 [p<0.001, F 127.6 ± 28.7 (SD) min; M 109.9 ± 28.6 min] and with GE at 1h and 2h. Repeat GE T1/2 values in 47 participants were significantly correlated (r= 0.459, p<0.001) with median difference of −6 min (mean −1.6, range −56 to 72 min). Bland-Altman plots showed Δ GE T1/2 similarly distributed across mean GE T1/2 100–155 minutes, and across studies conducted 90 to 600 days apart. Inter-subject variations in scintigraphic GE results are only slightly higher than the intra-subject measurements, which are also reproducible over time in healthy volunteers. Gender, but not BMI, is significantly associated with GE results.
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影响因子：
29.4
作者：
Parkman HP;Yates K;Hasler WL;Nguyen L;Pasricha PJ;Snape WJ;Farrugia G;Koch KL;Abell TL;McCallum RW;Lee L;Unalp-Arida A;Tonascia J;Hamilton F;National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
通讯作者：
National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium
影响因子：
5.9
作者：
Jones, KL;Russo, A;Horowitz, M
通讯作者：
Horowitz, M
影响因子：
--
作者：
CAMILLERI, M;COLEMONT, LJ;ZINSMEISTER, AR
通讯作者：
ZINSMEISTER, AR
影响因子：
29.4
作者：
Delgado-Aros, S;Cremonini, F;Camilleri, M
通讯作者：
Camilleri, M
影响因子：
9.8
作者：
Choi, MG;Camilleri, M;Nair, KS
通讯作者：
Nair, KS