Responsive neurostimulation with low-frequency stimulation.
Responsive neurostimulation with low-frequency stimulation.
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作者：
脑深部电刺激（DBS）和反应性神经刺激（RNS）根据关键试验和研究者推荐的治疗方案使用高频刺激（HFS）。然而，并非所有患者都对HFS有反应。在该回顾性病例系列中，10例植入RNS系统的患者程控为低频刺激（LFS）治疗癫痫发作;其中9例患者既往接受过HFS（100 Hz或更高）治疗。LFS定义为频率小于10 Hz。短脉冲持续时间增加至至少1000 msec。HFS患者在中位19个月（IQR 7-49）后的中位癫痫发作减少（MSR）为13%（IQR −67至54）。相比之下，与HFS相比，LFS与67%的MSR（IQR 13-95）相关，与植入前基线相比，LFS与76%的MSR（IQR 43-91）相关。HFS和LFS之间每小时输送的电荷和每天的脉冲没有显著差异，尽管LFS每天刺激的时间（228分钟）长于HFS（7分钟）。没有任何患者报告LFS特异性不良反应。LFS可以代表在接受RNS系统治疗的局灶性DRE患者中输送刺激的替代有效方法。
Deep brain stimulation (DBS) and responsive neurostimulation (RNS) use high frequency stimulation (HFS) per the pivotal trials and manufacturer-recommended therapy protocols. However, not all patients respond to HFS. In this retrospective case series, 10 patients implanted with the RNS System were programmed with Low Frequency Stimulation (LFS) to treat their seizures; 9 of these patients were previously treated with HFS (100 Hz or greater). LFS was defined as frequency less than 10 Hz. Burst duration was increased to at least 1000 msec. With HFS patients had a median seizure reduction (MSR) of 13% (IQR −67 to 54) after a median of 19 months (IQR 7–49). In contrast, LFS was associated with a 67% MSR (IQR 13–95) when compared to HFS and 76% MSR (IQR 43–91) when compared to baseline prior to implantation. Charge delivered per hour and pulses per day were not significantly different between HFS and LFS, although time stimulated per day was longer for LFS (228 min) than for HFS (7 min). There were no LFS-specific adverse effects reported by any of the patients. LFS could represent an alternative, effective method for delivering stimulation in focal DRE patients treated with the RNS System.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
丘脑前核的高频刺激使人类癫痫网络不同步
影响因子：
14.5
作者：
Yu, Tao;Wang, Xueyuan;Wang, Yuping
通讯作者：
Wang, Yuping
影响因子：
5.6
作者：
Fisher, Robert;Salanova, Vicenta;Graves, Nina
通讯作者：
Graves, Nina
DOI：
10.1111/ner.12435
发表时间：
2016-06
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Lim SN;Lee CY;Lee ST;Tu PH;Chang BL;Lee CH;Cheng MY;Chang CW;Tseng WE;Hsieh HY;Chiang HI;Wu T
通讯作者：
Wu T
Centromedian丘脑核对儿童和成人的癫痫症具有或没有前丘脑深脑刺激：一个回顾性病例系列。
DOI：
10.1016/j.seizure.2020.11.012
发表时间：
2021-01
期刊：
Seizure
影响因子：
--
作者：
Alcala-Zermeno JL;Gregg NM;Wirrell EC;Stead M;Worrell GA;Van Gompel JJ;Lundstrom BN
通讯作者：
Lundstrom BN