Models of toxicity of diacetyl and alternative diones.
Models of toxicity of diacetyl and alternative diones.
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DOI：
10.1016/j.tox.2017.02.011
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发表时间：
2017-08-01
期刊：
影响因子：
4.5
通讯作者：
Palmer SM
中科院分区：
文献类型：
--
作者：
Brass DM;Palmer SM
二乙酰（DA；2,3-丁二酮），化学式为(CH3CO)2，是一种挥发性有机化合物，呈深黄色，具有浓郁的黄油味和香气。这些特性使 DA 成为特别有用且常见的食品调味成分。然而，由于职业使用的增加，工人可能会在工作场所接触高浓度的蒸气。尽管被美国 FDA 列为“普遍认为安全”(GRAS)，但多种证据表明，暴露于高浓度 DA 蒸气会导致肺功能长期受损，肺功能测试表明受影响个体存在限制性或阻塞性气道狭窄。现在，越来越多的临床前研究已经解决了与 DA 暴露相关的短期和长期毒性问题，进一步深入了解了 DA 和相关二酮的毒性。本评论总结了这些观察结果。
Diacetyl (DA; 2,3-butanedione), with the chemical formula (CH3CO)2 is a volatile organic compound with a deep yellow color and a strong buttery flavor and aroma. These properties have made DA a particularly useful and common food flavoring ingredient. However, because of this increased occupational use, workers can be exposed to high vapor concentrations in the workplace. Despite being listed by the USFDA to be ‘generally regarded as safe’ (GRAS), multiple lines of evidence suggest that exposure to high concentrations of DA vapor causes long-term impairments in lung function with lung function testing indicating evidence of either restrictive or obstructive airway narrowing in affected individuals. A growing number of preclinical studies have now addressed the short and long-term toxicity associated with DA exposure providing further insight into the toxicity of DA and related diones. This review summarizes these observations.
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