3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity.
3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity.
复制标题
DOI：
10.1021/jf901512t
复制
发表时间：
2009-08-26
影响因子：
6.1
通讯作者：
Kurth MJ
中科院分区：
文献类型：
--
作者：
Yu GJ;Iwamoto S;Robins LI;Fettinger JC;Sparks TC;Lorsbach BA;Kurth MJ
A collection of ninety-one 3-(arylthiomethyl)isoxazole-4,5-dicarboxamides were prepared starting from dimethyl 3-(chloromethyl)isoxazole-4,5-dicarboxylate. The thioether moieties in these compounds were subsequently oxidized to give the corresponding 3-(arylsulfonylmethyl)isoxazole-4,5-dicarboxamides. By carefully controlling stoichiometry and reaction conditions, the C4 and C5 carbomethoxy groups could be differentially derivatized to carboxamides. A total of 182 trisubstituted isoxazoles are reported and deposited in the National Institutes of Health Molecular Repository; an 80 compound subset was evaluated for insecticidal activity.
登录
查看更多内容
影响因子：
--
作者：
Robins, Lori I.;Fettinger, James C.;Kurth, Mark J.
通讯作者：
Kurth, Mark J.
影响因子：
2.7
作者：
Epple, Robert;Azimioara, Mihai;Tian, Shin-Shay
通讯作者：
Tian, Shin-Shay
影响因子：
2.7
作者：
De Simone, G;Di Fiore, A;Supuran, CT
通讯作者：
Supuran, CT
影响因子：
2.1
作者：
Sato, K;Hyodo, M;Noyori, R
通讯作者：
Noyori, R
影响因子：
2
作者：
Choung, Wonken;Lorsbach, Beth A.;Kurth, Mark J.
通讯作者：
Kurth, Mark J.