Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families.
Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families.
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DOI：
10.1002/aur.226
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发表时间：
2012-02
期刊：
影响因子：
4.7
通讯作者：
Estes, Annette
中科院分区：
文献类型：
--
作者：
Bernier, Raphael;Gerdts, Jennifer;Munson, Jeff;Dawson, Geraldine;Estes, Annette
更广泛的自闭症表型在父母中进行了评估，这些父母有两个或更多患有ASD的孩子（多重自闭症），父母有不超过一个患有ASD的孩子（单纯自闭症），父母有一个没有ASD的发育迟缓的孩子，以及父母有典型发育的孩子。临床医生，天真的父母组成员的地位，评级更广泛的自闭症表型特征，从录像管理更广泛的自闭症表型症状量表（BPASS）。使用多变量方差分析和事后比较研究了四个评估领域（社会动机，会话技能，表达能力和限制性兴趣）BPASS评分的组间差异。此外，将未了解家庭状况的观察员对录像带的评分与了解家庭状况的观察员（非幼稚）对现场非幼稚的评分进行比较。研究结果表明，BPASS是一种抗评定者偏倚的工具。来自多重自闭症家庭的父母比其他组的父母表现出更多的自闭症表型特征。此外，来自单纯自闭症家庭的父母与发育迟缓或典型发育儿童的父母没有差异。最后，现场，非天真的评级和录像，天真的评级之间没有差异。这些发现表明，多重自闭症父母比单纯自闭症和对照父母更大程度地存在更广泛的自闭症表型特征，特别是在社交和沟通领域。此外，研究结果支持了这样一种观点，即遗传传播机制可能在有一个以上自闭症儿童的家庭和只有一个自闭症儿童的家庭之间存在差异。
The broader autism phenotype was assessed in parents who have two or more children with ASD (multiplex autism), parents who have no more than one child with ASD (simplex autism), parents who have a child with developmental delay without ASD, and parents who have typically developing children. Clinicians, naive to parent group membership status, rated broader autism phenotype characteristics from videotaped administration of the Broader Autism Phenotype Symptom Scale (BPASS). Differences among groups in BPASS scores in the four assessed domains (social motivation, conversational skills, expressiveness, and restricted interests) were examined using multivariate ANOVA and post-hoc comparisons. Further, ratings of videotapes by observers naive to family status were compared to live, non-naïve ratings by observers who were aware of family status (non-naïve). Findings demonstrate that the BPASS is an instrument resistant to rater bias. Parents from multiplex autism families showed significantly more autism phenotype characteristics than the parents in the other groups. Moreover, the parents from simplex autism families did not differ from the parents of children with developmental delay or typical development. Finally, no differences between live, non-naive ratings and videotaped, naive ratings were observed. These findings suggest that characteristics of the broader autism phenotype, specifically in the social and communication domains, are present in multiplex autism parents to a greater degree than simplex autism and control parents. Further, the results provide support for the notion that genetic transmission mechanisms may differ between families with more than one child with autism and families with only one child with autism.
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影响因子：
7.6
作者：
Pickles, A;Starr, E;Rutter, M
通讯作者：
Rutter, M
影响因子：
6.9
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
通讯作者：
RUTTER, M
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M
DOI：
10.1111/j.1469-7610.1994.tb02300.x
发表时间：
1994-07-01
影响因子：
7.6
作者：
BOLTON, P;MACDONALD, H;RUTTER, M
通讯作者：
RUTTER, M
影响因子：
3.2
作者：
BaronCohen, S;Hammer, J
通讯作者：
Hammer, J