Experimental study on novel biodegradable Zn-Fe-Si alloys.
Experimental study on novel biodegradable Zn-Fe-Si alloys.
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DOI：
10.1002/jbm.b.35075
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发表时间：
2022-10
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影响因子：
--
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中科院分区：
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--
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生物可吸收金属因其作为可降解植入器械材料的潜在用途而越来越受到关注。锌合金由于具有良好的生物相容性和良好的降解速率而显示出巨大的应用前景。然而，历史上锌合金很难在强度、延展性、生物相容性和腐蚀速率之间保持适当的平衡。在这项研究中，微观结构，化学成分，机械性能，生物相容性，和腐蚀速率的一种新的三元锌-铁-硅（Zn-Fe-Si）合金系统进行了研究，作为一种新的材料，潜在的生物可降解植入物的应用。结果表明，原位生成的Fe-Si金属间化合物相在保持良好塑性的同时提高了材料的机械强度。加入Fe-Si增强体后，Zn合金的显微硬度提高了43%。拉伸强度增加了高达76%，而断裂伸长率保持在30%以上。间接细胞毒性试验表明Zn-Fe-Si体系具有良好的生物相容性。浸泡试验表明，Zn-Fe-Si体系的腐蚀速率与纯Zn没有统计学差异。为了理解潜在的相形成机理，还通过相演化和吉布斯自由能分析研究了该三元体系在加工过程中的反应过程。结果表明，Zn-Fe-Si三元体系是一种很有前途的可生物吸收金属医疗器械新材料。
Bioabsorbable metals are increasingly attracting attention for their potential use as materials for degradable implant devices. Zinc (Zn) alloys have shown great promises due to their good biocompatibility and favorable degradation rate. However, it has been difficult to maintain an appropriate balance among strength, ductility, biocompatibility, and corrosion rate for Zn alloys historically. In this study, the microstructure, chemical composition, mechanical properties, biocompatibility, and corrosion rate of a new ternary zinc-iron-silicon (Zn-Fe-Si) alloy system was studied as a novel material for potential biodegradable implant applications. The results demonstrated that the in-situ formed Fe-Si intermetallic phases enhanced the mechanical strength of the material while maintaining a favorable ductility. With Fe-Si reinforcements, the microhardness of the Zn alloys was enhanced by up to 43%. The tensile strength was increased by up to 76% while elongation to failure remained above 30%. Indirect cytotoxicity testing showed the Zn-Fe-Si system had good biocompatibility. Immersion testing revealed the corrosion rate of Zn-Fe-Si system was not statistically different from pure Zn. To understand the underlying phase formation mechanism, the reaction process in this ternary system during the processing was also studied via phase evolution and Gibbs free energy analysis. The results suggest the Zn-Fe-Si ternary system is a promising new material for bioabsorbable metallic medical devices.
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影响因子：
6.2
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
3
作者：
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Li, Xiaochun
DOI：
10.1016/s0921-5093(00)00929-1
发表时间：
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影响因子：
6.4
作者：
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通讯作者：
Man, HC