The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.
The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.
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DOI：
10.1016/j.ajhg.2022.05.005
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发表时间：
2022-07-07
影响因子：
9.8
通讯作者：
中科院分区：
文献类型：
--
作者：
儿童时期偏离正常的生长与以后的生活中神经性厌食症（AN）和肥胖有关。在这项研究中，我们研究了AN和BMI的多基因评分（PGSs）是否与生命头二十年的生长轨迹相关。计算了雅芳父母和儿童纵向研究（ALSPAC; n = 8，654）参与者的AN PGSs和BMI PGSs。使用广义（混合）线性模型，我们将PGS与体重、身高、体重指数（BMI）、脂肪质量指数（FMI）、瘦体重指数（LMI）和骨矿物质密度（BMD）的轨迹相关联。AN PGSs高一个标准差（SD）的女性参与者在6.5至24岁之间的BMI增长平均较慢0.004%，在10至24岁之间的BMD增长较慢0.4%。在整个儿童期，较高的BMI PGSs与BMI、FMI、LMI、BMD和体重轨迹的快速增长相关。与具有低AN PGS和低BMI PGS的女性参与者相比，具有高AN PGS和低BMI PGS的女性参与者显示出较慢的生长。我们的结论是，AN PGSs和BMI PGSs有可检测的性别特异性影响的增长轨迹。具有高AN PGS和低BMI PGS的女性参与者可能构成AN的高风险组，因为与两种特征上具有高PGS的同龄人相比，她们的生长较慢。需要进一步的研究来更好地了解AN PGS和BMI PGS如何共同影响儿童期的生长，以及高BMI PGS是否可以减轻高AN PGS的影响。
Growth deviating from the norm during childhood has been associated with anorexia nervosa (AN) and obesity later in life. In this study, we examined whether polygenic scores (PGSs) for AN and BMI are associated with growth trajectories spanning the first two decades of life. AN PGSs and BMI PGSs were calculated for participants of the Avon Longitudinal Study of Parents and Children (ALSPAC; n = 8,654). Using generalized (mixed) linear models, we associated PGSs with trajectories of weight, height, body mass index (BMI), fat mass index (FMI), lean mass index (LMI), and bone mineral density (BMD). Female participants with AN PGSs one standard deviation (SD) higher had, on average, 0.004% slower growth in BMI between the ages 6.5 and 24 years and a 0.4% slower gain in BMD between the ages 10 and 24 years. Higher BMI PGSs were associated with faster growth for BMI, FMI, LMI, BMD, and weight trajectories in both sexes throughout childhood. Female participants with both a high AN PGS and a low BMI PGS showed slower growth compared to those with both a low AN PGS and a low BMI PGS. We conclude that AN PGSs and BMI PGSs have detectable sex-specific effects on growth trajectories. Female participants with a high AN PGS and low BMI PGS likely constitute a high-risk group for AN, as their growth was slower compared to their peers with high PGSs on both traits. Further research is needed to better understand how the AN PGS and the BMI PGS co-influence growth during childhood and whether a high BMI PGS can mitigate the effects of a high AN PGS.
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影响因子：
8.8
作者：
Herle M;Smith AD;Kininmonth A;Llewellyn C
通讯作者：
Llewellyn C
影响因子：
6.9
作者：
Klump, K. L.;Culbert, K. M.;Slane, J. D.;Burt, S. A.;Sisk, C. L.;Nigg, J. T.
通讯作者：
Nigg, J. T.
影响因子：
--
作者：
Hellwege JN;Keaton JM;Giri A;Gao X;Velez Edwards DR;Edwards TL
通讯作者：
Edwards TL
影响因子：
8.2
作者：
Daly, Michael;Sutin, Angelina R.;Robinson, Eric
通讯作者：
Robinson, Eric
DOI：
10.1002/ajmg.b.32709
发表时间：
2019-09-01
影响因子：
2.8
作者：
Hubel, Christopher;Gaspar, Helena A.;Breen, Gerome
通讯作者：
Breen, Gerome