Degradable and Removable Tough Adhesive Hydrogels.
Degradable and Removable Tough Adhesive Hydrogels.
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可降解和可拆卸的坚韧粘合剂水凝胶。
DOI：
10.1002/adma.202008553
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Mooney DJ
中科院分区：
文献类型：
--
作者：
Freedman BR;Uzun O;Luna NMM;Rock A;Clifford C;Stoler E;Östlund-Sholars G;Johnson C;Mooney DJ
坚韧的粘合剂水凝胶的发展已经使得能够前所未有地粘附到整个身体的湿的和移动的组织表面，但是通常由不可降解的组分组成。在这里，我们开发了一个家庭的可降解的坚韧的粘合剂水凝胶含有约90%的水通过将共价网络可降解交联剂和可水解的离子交联的主链聚合物。在体外加速条件和长达16周的体内条件下测试了这些新制剂的机械韧性、粘附力和降解。这些可降解的坚韧粘合剂被设计成具有与不可降解的坚韧粘合剂相当的机械和粘合性能，能够实现> 20倍于其初始长度的拉伸，断裂能> 6 kJ/m2，并且粘合能> 1000 J/m2。所有可降解系统在体外加速老化条件下均在2周内完全降解，在体内加速老化条件下均在数周至数月内完全降解，具体取决于所选的可降解交联剂。在植入1、2、4、8和16周后，所有组均观察到良好的生物相容性，纤维包裹最小，无器官毒性迹象。通过化学试剂处理实现粘合剂的按需去除，其不会对小鼠的下层皮肤组织造成损伤。该系列粘合剂的广泛通用性为许多体内适应症提供了基础。
The development of tough adhesive hydrogels has enabled unprecedented adhesion to wet and moving tissue surfaces throughout the body but are typically composed of non-degradable components. Here, we develop a family of degradable tough adhesive hydrogels containing ~90% water by incorporating covalently networked degradable crosslinkers and hydrolyzable ionically crosslinked main chain polymers. Mechanical toughness, adhesion, and degradation of these new formulations was tested in both accelerated in vitro conditions and up to 16-weeks in vivo. These degradable tough adhesives were engineered with equivalent mechanical and adhesive properties to nondegradable tough adhesives, capable of achieving stretches > 20 times their initial length, fracture energies >6kJ/m2, and adhesion energies >1000J/m2. All degradable systems showed complete degradation within 2-weeks under accelerated aging conditions in vitro and weeks to months in vivo depending on the degradable crosslinker selected. Excellent biocompatibility was observed for all groups after 1, 2, 4, 8, and 16 weeks of implantation, with minimal fibrous encapsulation and no signs of organ toxicity. On-demand removal of the adhesive was achieved with treatment of chemical agents which did not cause damage to underlying skin tissue in mice. The broad versatility of this family of adhesives provides the foundation for numerous in vivo indications.
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影响因子：
4.9
作者：
Browning, M. B.;Cereceres, S. N.;Luong, P. T.;Cosgriff-Hernandez, E. M.
通讯作者：
Cosgriff-Hernandez, E. M.
DOI：
10.14245/kjs.2013.10.1.44
发表时间：
2013-03
期刊：
Korean Journal of Spine
影响因子：
--
作者：
Lee SH;Park CW;Lee SG;Kim WK
通讯作者：
Kim WK
影响因子：
3
作者：
Altinisik, Aylin;Yurdakoc, Kadir
通讯作者：
Yurdakoc, Kadir
影响因子：
13.6
作者：
Blacklow, S. O.;Li, J.;Mooney, D. J.
通讯作者：
Mooney, D. J.
影响因子：
14
作者：
Koshy, Sandeep T.;Ferrante, Thomas C.;Lewin, Sarah A.;Mooney, David J.
通讯作者：
Mooney, David J.