Dual-specificity MAP kinase phosphatases in health and disease.
Dual-specificity MAP kinase phosphatases in health and disease.
复制标题
DOI：
10.1016/j.bbamcr.2018.09.002
复制
发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Keyse SM
中科院分区：
文献类型：
--
作者：
Seternes OM;Kidger AM;Keyse SM
已经确定的是，双特异性MAP激酶磷酸酶（MKPs）家族在哺乳动物细胞和组织中MAP激酶异构体的受调节的去磷酸化和失活中起关键作用。MKP提供了这些关键信号传导途径的时空反馈控制机制，但也可以介导不同MAP激酶级联之间的串扰，并促进MAP激酶途径与其他关键信号传导模块之间的相互作用。随着我们对MKPs的调节、底物特异性和催化机制的了解已经成熟，最近使用遗传模型的工作揭示了MKPs的关键生理功能，并且还揭示了在调节与人类疾病相关的信号传导的病理生理结果中的潜在重要作用。这些疾病包括癌症、糖尿病、炎症和神经退行性疾病。希望这种理解将揭示疾病的新治疗靶点和生物标志物，从而有助于更有效地诊断和治疗这些使人衰弱且往往致命的疾病。对双特异性MAP激酶磷酸酶（MKPs）的全面综述重点是MKPs在健康和疾病中MAPK信号转导的调节。涵盖MKPs在炎症、肥胖/糖尿病、癌症和神经退行性疾病中的作用
It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions between MAP kinase pathways and other key signalling modules. As our knowledge of the regulation, substrate specificity and catalytic mechanisms of MKPs has matured, more recent work using genetic models has revealed key physiological functions for MKPs and also uncovered potentially important roles in regulating the pathophysiological outcome of signalling with relevance to human diseases. These include cancer, diabetes, inflammatory and neurodegenerative disorders. It is hoped that this understanding will reveal novel therapeutic targets and biomarkers for disease, thus contributing to more effective diagnosis and treatment for these debilitating and often fatal conditions. A comprehensive review of the dual-specificity MAP kinase Phosphatases (MKPs) Focus is on MKPs in the regulation of MAPK signalling in health and disease. Covers roles of MKPs in inflammation, obesity/diabetes, cancer and neurodegeneration
登录
查看更多内容
DOI：
10.1073/pnas.90.11.5292
发表时间：
1993-06-01
影响因子：
11.1
作者：
CHARLES, CH;SUN, H;TONKS, NK
通讯作者：
TONKS, NK
影响因子：
5.3
作者：
Christie, GR;Williams, DJ;Keyse, SM
通讯作者：
Keyse, SM
DOI：
10.1084/jem.20071728
发表时间：
2008-06-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cao W;Bao C;Padalko E;Lowenstein CJ
通讯作者：
Lowenstein CJ
影响因子：
3.9
作者：
Degl'Innocenti, Debora;Romeo, Paola;Borrello, Maria Grazia
通讯作者：
Borrello, Maria Grazia
影响因子：
10.6
作者：
Barthas, Florent;Humo, Muris;Yalcin, Ipek
通讯作者：
Yalcin, Ipek