The false-negative rate of sentinel node biopsy in patients with breast cancer: a meta-analysis.
The false-negative rate of sentinel node biopsy in patients with breast cancer: a meta-analysis.
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DOI：
10.1007/s00268-012-1623-z
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发表时间：
2012-09
影响因子：
2.6
通讯作者：
Krag, David
中科院分区：
文献类型：
--
作者：
Pesek, Sarah;Ashikaga, Taka;Krag, Lars Erik;Krag, David
In sentinel node surgery for breast cancer, procedural accuracy is assessed by calculating the false-negative rate. It is important to measure this since there are potential adverse outcomes from missing node metastases. We performed a meta-analysis of published data to assess which method has achieved the lowest false-negative rate. We found 3588 articles concerning sentinel nodes and breast cancer published from 1993 through mid-2011; 183 articles met our inclusion criteria. The studies described in these 183 articles included a total of 9306 patients. We grouped the studies by injection material and injection location. The false-negative rates were analyzed according to these groupings and also by the year in which the articles were published. There was significant variation in the false-negative rate over time with a trend to higher rates over time. There was significant variation related to injection material. The use of blue dye alone was associated with the highest false-negative rate. Inclusion of a radioactive tracer along with blue dye resulted in a significantly lower false-negative rate. Although there were variations in the false-negative rate according to injection location, none were significant. This meta-analysis also indicates a significant change over time in the false-negative rate. The use of blue dye should be accompanied by a radioactive tracer to achieve a significantly lower false-negative rate. Location of injection did not have a significant impact on the false-negative rate. Given the limitations of acquiring appropriate data, the false-negative rate should not be used as a metric for training or quality control.
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DOI：
10.1024/1023-9332.5.5.217
发表时间：
1999-01-01
期刊：
Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera
影响因子：
--
作者：
Bembenek, A;Reuhl, T;Schlag, P M
通讯作者：
Schlag, P M
影响因子：
1.9
作者：
Casalegno, PS;Sandrucci, S;Mussa, A
通讯作者：
Mussa, A
影响因子：
168.9
作者：
Borgstein, PJ;Meijer, S;Pijpers, R
通讯作者：
Pijpers, R
影响因子：
8.4
作者：
Bobin, JY;Zinzindohoue, C;Roy, P
通讯作者：
Roy, P
影响因子：
3.2
作者：
Chintamani;Tandon, Megha;Saxena, Sunita
通讯作者：
Saxena, Sunita