The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: clues to mechanisms of carcinogenesis.
The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: clues to mechanisms of carcinogenesis.
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第九届戈登·汉密尔顿-费尔利纪念演讲。
DOI：
10.1038/bjc.1989.137
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发表时间：
1989
影响因子：
8.8
通讯作者：
KnudsonJr,AG
中科院分区：
文献类型：
--
作者：
KnudsonJr,AG
对人类遗传性癌症，特别是视网膜母细胞瘤的研究，已经确定了一类与癌基因不同的癌症基因。后一组基因通过表达发挥作用，而前一组基因是由于正常表达失败而发挥作用。原发性癌基因异常似乎在某些肿瘤中起关键的起始作用，特别是白血病、淋巴瘤和某些肉瘤。相反，抑癌基因（肿瘤抑制基因）似乎是重要的启动几个实体瘤的儿童，以及一些常见的癌症的成人。这两种类型显然都涉及肿瘤进展和转移。几乎每一种癌症都可能以遗传形式发生，因此抗癌基因在人类癌症起源中的作用可能是相当大的。原型抑癌基因是视网膜母细胞瘤的抑癌基因。对于这种肿瘤，隐性机制已被分子手段证明，基因已被克隆。基因（或基因产物）替代疗法有可能实现.
The study of hereditary cancer in humans, notably retinoblastoma, has identified a category of cancer genes that is different from that of the oncogenes. Whereas the latter group of genes exerts its effect through expression, the former does so as a result of failure of normal expression. Primary oncogene abnormality seems to play a crucial initiating role in certain neoplasms, particularly leukaemias, lymphomas and some sarcomas. In contrast, anti-oncogenes (tumour suppressor genes) appear to be important in the initiation of several solid tumours of children, as well as some common carcinomas of adults. Both classes are apparently involved in tumour progression and metastasis. Virtually every kind of cancer can occur in hereditary form, so the role of anti-oncogenes in the origin of human cancers may be considerable. The prototypic anti-oncogene has been that for retinoblastoma. For this tumour the recessive mechanism has been demonstrated by molecular means, and the gene has been cloned. The possibility has been suggested that gene (or gene product) replacement therapy could be accomplished.
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影响因子：
56.9
作者：
R. Sparkes;MC Sparkes;M. Wilson;JW Towner;W. Benedict;A. Murphree;J. Yunis
通讯作者：
R. Sparkes;MC Sparkes;M. Wilson;JW Towner;W. Benedict;A. Murphree;J. Yunis
影响因子：
56.9
作者：
HUANG, HJS;YEE, JK;LEE, WH
通讯作者：
LEE, WH
视网膜母细胞瘤：一种原型遗传性肿瘤。
影响因子：
4
作者：
A. Knudson
通讯作者：
A. Knudson
影响因子：
56.9
作者：
LEPPERT, M;DOBBS, M;WHITE, R
通讯作者：
WHITE, R
散发性双侧视网膜母细胞瘤和 13q-染色体缺失。
DOI：
10.1002/mpo.2950020404
发表时间：
1976
期刊：
Medical and pediatric oncology
影响因子：
--
作者：
U. Francke;F. Kung
通讯作者：
F. Kung