Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation.
Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation.
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在没有早期种系分离的情况下，有丝分裂基因转换在驱动植物和其他物种的遗传变异方面与减数分裂转换一样重要
DOI：
10.1371/journal.pbio.3001164
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发表时间：
2021-03
期刊：
影响因子：
9.8
通讯作者：
Yang S
中科院分区：
文献类型：
--
作者：
Jia X;Zhang Q;Jiang M;Huang J;Yu L;Traw MB;Tian D;Hurst LD;Yang S
与普通减数分裂基因转换相反，有丝分裂基因转换由于其非常罕见，常常被忽视为影响等位基因多样性的过程。我们表明，如果有足够多的减数分裂前细胞分裂，如在许多生物体没有早期生殖系隔离，如植物，这是一个不安全的位置。通过对110万株水稻植株的检测，我们确定了每一次有丝分裂的有丝分裂基因转换事件的速率比减数分裂速率低2个数量级。然而，由于合子和配子之间有大量的有丝分裂，并且由于有丝分裂道长度长，减数分裂和有丝分裂基因转换在从合子转换为配子的标记数量方面可以具有大致相等的重要性。即使我们假设减数分裂前的细胞分裂次数很少（大约40次），这也是成立的，正如在拟南芥中所看到的那样。在酵母中也观察到与长道相关的低有丝分裂率，表明结果的一般性。对于每个减数分裂事件之间有许多有丝分裂的物种，有丝分裂基因转换不应被忽视。
In contrast to common meiotic gene conversion, mitotic gene conversion, because it is so rare, is often ignored as a process influencing allelic diversity. We show that if there is a large enough number of premeiotic cell divisions, as seen in many organisms without early germline sequestration, such as plants, this is an unsafe position. From examination of 1.1 million rice plants, we determined that the rate of mitotic gene conversion events, per mitosis, is 2 orders of magnitude lower than the meiotic rate. However, owing to the large number of mitoses between zygote and gamete and because of long mitotic tract lengths, meiotic and mitotic gene conversion can be of approximately equivalent importance in terms of numbers of markers converted from zygote to gamete. This holds even if we assume a low number of premeiotic cell divisions (approximately 40) as witnessed in Arabidopsis. A low mitotic rate associated with long tracts is also seen in yeast, suggesting generality of results. For species with many mitoses between each meiotic event, mitotic gene conversion should not be overlooked.
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正常细胞的基因组测序揭示了发育谱系和突变过程。
影响因子：
64.8
作者：
Behjati, Sam;Huch, Meritxell;van Boxtel, Ruben;Karthaus, Wouter;Wedge, David C.;Tamuri, Asif U.;Martincorena, Inigo;Petljak, Mia;Alexandrov, Ludmil B.;Gundem, Gunes;Tarpey, Patrick S.;Roerink, Sophie;Blokker, Joyce;Maddison, Mark;Mudie, Laura;Robinson, Ben;Nik-Zainal, Serena;Campbell, Peter;Goldman, Nick;van de Wetering, Marc;Cuppen, Edwin;Clevers, Hans;Stratton, Michael R.
通讯作者：
Stratton, Michael R.
影响因子：
16.6
作者：
Gerstein, A. C.;Kuzmin, A.;Otto, S. P.
通讯作者：
Otto, S. P.
影响因子：
4.5
作者：
Andersen SL;Zhang A;Dominska M;Moriel-Carretero M;Herrera-Moyano E;Aguilera A;Petes TD
通讯作者：
Petes TD
影响因子：
64.8
作者：
Flot, Jean-Francois;Hespeels, Boris;Van Doninck, Karine
通讯作者：
Van Doninck, Karine
DOI：
10.1073/pnas.0605778103
发表时间：
2006-08-22
影响因子：
11.1
作者：
Barbera, Maria A.;Petes, Thomas D.
通讯作者：
Petes, Thomas D.