Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.
Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study.
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DOI：
10.1007/s00125-018-4720-1
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发表时间：
2018-12
期刊：
影响因子：
8.2
通讯作者：
Scherer PE
中科院分区：
文献类型：
--
作者：
Neeland IJ;Singh S;McGuire DK;Vega GL;Roddy T;Reilly DF;Castro-Perez J;Kozlitina J;Scherer PE
神经酰胺是神经鞘脂类，在临床前研究中参与胰岛素抵抗。我们假设血浆神经酰胺与多种族人群的体脂分布、胰岛素抵抗和2型糖尿病发病率有关。在达拉斯心脏研究中，共有1557名无2型糖尿病的参与者接受了代谢生物标志物、脂肪库（MRI）和血浆神经酰胺（液相色谱-质谱）的测量。7年后评估糖尿病结局。分析了基线时体脂和胰岛素抵抗与神经酰胺的关系，以及神经酰胺与糖尿病结局的关系。该队列的平均年龄为43岁，58%为女性，45%为非洲裔美国人，平均BMI为28 kg/m2。总胆固醇水平与所有神经酰胺相关，但较高的三酰甘油和较低的高密度脂蛋白胆固醇和脂联素仅与饱和脂肪酸链神经酰胺相关（p<0.0003）。在调整临床特征和体脂总量后，内脏脂肪组织与饱和脂肪酸神经酰胺呈正相关（每SD， β= 0.16至0.18），与多不饱和脂肪酸神经酰胺负相关（β= - 0.14至- 0.16,p<0.001）。下体皮下脂肪与内脏脂肪表现出相反的模式。HOMA-IR与饱和神经酰胺呈正相关（β=0.08 ~ 0.09, p<0.001），与多不饱和神经酰胺呈负相关（β= - 0.06 ~ - 0.07, p<0.05）。经临床因素调整后，神经酰胺与2型糖尿病的发生无关。血浆神经酰胺与代谢和功能失调肥胖的成像指标之间存在复杂的生物学关系。神经酰胺在连接内脏脂肪和胰岛素抵抗的代谢功能障碍的共同途径中的作用需要进一步研究。
Ceramides are sphingolipids that contribute to insulin resistance in preclinical studies. We hypothesised that plasma ceramides would be associated with body fat distribution, insulin resistance and incident type 2 diabetes in a multi-ethnic cohort. A total of 1557 participants in the Dallas Heart Study without type 2 diabetes underwent measurements of metabolic biomarkers, fat depots by MRI, and plasma ceramides by liquid chromatography-mass spectrometry. Diabetes outcomes were assessed after 7 years. Associations of body fat and insulin resistance with ceramides at baseline and of ceramides with incident diabetes outcomes were analysed. The cohort had mean age 43 years, with 58% women, 45% African-Americans and mean BMI 28 kg/m2. Total cholesterol levels were associated with all ceramides, but higher triacylglycerols and lower HDL-cholesterol and adiponectin were associated only with saturated fatty acid chain ceramides (p<0.0003). After adjusting for clinical characteristics and total body fat, visceral adipose tissue was positively associated with saturated fatty acid ceramides (per SD, β= 0.16 to 0.18) and inversely associated with polyunsaturated fatty acid ceramides (β= −0.14 to −0.16, p<0.001 for all). Lower-body subcutaneous fat showed an opposite pattern to that for visceral fat. HOMA-IR was positively associated with saturated (β=0.08 to 0.09, p<0.001) and inversely with polyunsaturated ceramides (β=−0.06 to −0.07, p<0.05). Ceramides were not associated with incident type 2 diabetes after adjustment for clinical factors. Plasma ceramides demonstrate a biologically complex relationship with metabolic and imaging indicators of dysfunctional adiposity. The role of ceramides in a shared pathway of metabolic dysfunction linking visceral adiposity and insulin resistance requires further investigation.
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影响因子：
5.8
作者：
de la Maza, M. P.;Rodriguez, J. M.;Bunout, D.
通讯作者：
Bunout, D.
影响因子：
1.9
作者：
Blachnio-Zabielska, Agnieszka U.;Baranowski, Marcin;Hirnle, Tomasz;Zabielski, Piotr;Lewczuk, Anna;Dmitruk, Iwona;Gorski, Jan
通讯作者：
Gorski, Jan
内脏肥胖对糖异生中甘油途径的影响。
DOI：
10.1016/j.metabol.2016.11.008
发表时间：
2017-02
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Neeland IJ;Hughes C;Ayers CR;Malloy CR;Jin ES
通讯作者：
Jin ES
影响因子：
13.8
作者：
Petersen MC;Shulman GI
通讯作者：
Shulman GI
影响因子：
24
作者：
Chandra, Alvin;Neeland, Ian J.;Turer, Aslan T.
通讯作者：
Turer, Aslan T.