Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation.
Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation.
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DOI：
10.1016/j.devcel.2009.12.019
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发表时间：
2010-03-16
影响因子：
11.8
通讯作者：
Sucov HM
中科院分区：
文献类型：
--
作者：
Li P;Pashmforoush M;Sucov HM
In many experimental models and clinical examples, defects in the differentiation of the second heart field (SHF) and heart outflow tract septation defects are combined, although the mechanistic basis for this relationship has been unclear. We found that as the initial SHF population incorporates into the outflow tract, it is replenished from the surrounding progenitor territory. In retinoic acid (RA) receptor mutant mice, this latter process fails, and the outflow tract is shortened and misaligned as a result. As an additional consequence, the outflow tract is misspecified along its proximal-distal axis, which results in ectopic expression of TGFβ2 and ectopic mesenchymal transformation of the endocardium. Reduction of TGFβ2 gene dosage in the RA receptor deficient background restores septation but does not rescue alignment defects, indicating that excess TGFβ causes septation defects. This may be a common pathogenic pathway when second heart field and septation defects are coupled.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1073/pnas.0604604103
发表时间：
2006-07-25
影响因子：
11.1
作者：
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