Cell death mechanisms in head and neck cancer cells in response to low and high-LET radiation
Cell death mechanisms in head and neck cancer cells in response to low and high-LET radiation
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DOI：
10.1017/erm.2021.31
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发表时间：
2022-01-12
影响因子：
6.2
通讯作者：
Parsons, Jason L.
中科院分区：
文献类型：
--
作者：
Fabbrizi, Maria Rita;Parsons, Jason L.
关键词：
头颈部鳞状细胞癌（HNSCC）是一种常见的恶性肿瘤，发生在咽喉，喉，鼻，鼻窦和口腔内或周围，主要采用化疗和放疗（RT）联合治疗。RT的主要目标是杀死足够的癌细胞群，同时保护周围的正常和健康组织。几十年来，常规光子RT实现这一目标的机制已被广泛研究，但对响应于RT增加线性能量转移（LET）（包括质子束治疗和重离子）而激活的细胞死亡途径知之甚少。在这里，我们提供了一个最新的审查所观察到的低与高LET RT在HNSCC细胞模型的放射生物学效应，特别是在特定的细胞死亡机制，包括凋亡，坏死，自噬，衰老和有丝分裂死亡的背景下。我们还详细介绍了一些目前的治疗策略，靶向细胞死亡途径，已被调查，以提高放射敏感性的HNSCC细胞响应RT，包括那些可能与临床机会，最终患者的利益。
Head and neck squamous cell carcinoma (HNSCC) is a common malignancy that develops in or around the throat, larynx, nose, sinuses and mouth, and is mostly treated with a combination of chemo- and radiotherapy (RT). The main goal of RT is to kill enough of the cancer cell population, whilst preserving the surrounding normal and healthy tissue. The mechanisms by which conventional photon RT achieves this have been extensively studied over several decades, but little is known about the cell death pathways that are activated in response to RT of increasing linear energy transfer (LET), including proton beam therapy and heavy ions. Here, we provide an up-to-date review on the observed radiobiological effects of low- versus high-LET RT in HNSCC cell models, particularly in the context of specific cell death mechanisms, including apoptosis, necrosis, autophagy, senescence and mitotic death. We also detail some of the current therapeutic strategies targeting cell death pathways that have been investigated to enhance the radiosensitivity of HNSCC cells in response to RT, including those that may present with clinical opportunities for eventual patient benefit.
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