Integrin-mediated regulation of epidermal wound functions.
Integrin-mediated regulation of epidermal wound functions.
复制标题
整联蛋白介导的表皮伤口功能调节。
DOI：
10.1007/s00441-016-2446-2
复制
发表时间：
2016-09
影响因子：
3.6
通讯作者：
Van de Water, Livingston
中科院分区：
文献类型：
--
作者：
DiPersio, C. Michael;Zheng, Rui;Kenney, James;Van de Water, Livingston
在皮肤伤口愈合期间，角质形成细胞增殖和迁移对于再上皮化至关重要。此外，表皮将生长因子、细胞因子、蛋白酶和基质细胞蛋白分泌到伤口微环境中，其修饰细胞外基质并刺激控制炎症反应、促进血管生成并促进组织收缩和重塑的其他伤口细胞。伤口角质形成细胞表达至少七种不同的整合素-细胞外基质的主要细胞粘附受体-共同控制基本的细胞自主功能，以确保适当的上皮再生，包括迁移，增殖，存活和基底膜组装（图1，箭头1）。此外，近年来已经变得明显的是，一些整合素可以调节来自伤口表皮的旁分泌信号，所述旁分泌信号刺激参与血管生成、收缩和炎症的其他伤口细胞（图1，箭头2和3）。重要的是，表皮中的异常整联蛋白表达或功能可能有助于伤口病理学，例如过度旺盛愈合（例如，增生性瘢痕形成）或减少的愈合（例如，慢性伤口）。在这篇综述中，我们讨论了目前的知识整合素在表皮中的功能，这意味着他们有吸引力的治疗目标，以促进伤口愈合或治疗伤口病理。我们还讨论了多种整合素在伤口表皮中发挥的复杂作用所带来的挑战，这些整合素可能通过细胞外基质重塑来调节，从而决定配体的可用性。事实上，了解不同的整合素功能如何在伤口表皮中暂时协调，以及哪些整合素功能在病理性伤口中出错，对于确定如何最好地在临床上靶向它们以实现最大的治疗益处将是重要的。
During cutaneous wound healing, keratinocyte proliferation and migration are critical for re-epithelialization. In addition, the epidermis secretes growth factors, cytokines, proteases, and matricellular proteins into the wound microenvironment that modify the extracellular matrix and stimulate other wound cells that control the inflammatory response, promote angiogenesis, and facilitate tissue contraction and remodeling. Wound keratinocytes express at least seven different integrins - the major cell adhesion receptors for the extracellular matrix - that collectively control essential cell-autonomous functions to ensure proper re-epithelialization, including migration, proliferation, survival, and basement membrane assembly (Fig. 1, arrow 1). Moreover, it has become evident in recent years that some integrins can regulate paracrine signals from wound epidermis that stimulate other wound cells involved in angiogenesis, contraction and inflammation (Fig. 1, arrows 2 and 3). Importantly, it is likely that abnormal integrin expression or function in the epidermis contributes to wound pathologies such as over-exuberant healing (e.g., hypertrophic scar formation) or diminished healing (e.g., chronic wounds). In this review, we discuss current knowledge of integrin function in the epidermis, which implicates them as attractive therapeutic targets to promote wound healing or treat wound pathologies. We also discuss challenges that arise from the complex roles that multiple integrins play in wound epidermis, which may be regulated through extracellular matrix remodeling that determines ligand availability. Indeed, understanding how different integrin functions are temporally coordinated in wound epidermis, and which integrin functions go awry in pathological wounds, will be important to determine how best to target them clinically to achieve maximum therapeutic benefit.
登录
查看更多内容
整联蛋白α3β1在局灶性粘连中的不同功能和α6β4/bullous子型抗原抗原在新的稳定锚定接触（SAC）的角质形成细胞中：与Hemidesmosmosys的关系。
影响因子：
7.8
作者：
Carter, W G;Kaur, P;Gil, S G;Gahr, P J;Wayner, E A
通讯作者：
Wayner, E A
影响因子：
7.5
作者：
Delon, Isabelle;Brown, Nicholas H.
通讯作者：
Brown, Nicholas H.
影响因子：
11.4
作者：
Brakebusch, C;Grose, R;Fässler, R
通讯作者：
Fässler, R
DOI：
10.1177/1534734607301394
发表时间：
2007-06-01
期刊：
The international journal of lower extremity wounds
影响因子：
--
作者：
Agren, Magnus S;Werthen, Maria
通讯作者：
Werthen, Maria
影响因子：
6
作者：
Chen, JC;Diacovo, TG;Zutter, MM
通讯作者：
Zutter, MM