Comparison of Oncologic Outcomes between Carbon Ion Radiotherapy and Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer.
Comparison of Oncologic Outcomes between Carbon Ion Radiotherapy and Stereotactic Body Radiotherapy for Early-Stage Non-Small Cell Lung Cancer.
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DOI：
10.3390/cancers13020176
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发表时间：
2021-01-06
期刊：
影响因子：
5.2
通讯作者：
Ohno T
中科院分区：
文献类型：
--
作者：
Miyasaka Y;Komatsu S;Abe T;Kubo N;Okano N;Shibuya K;Shirai K;Kawamura H;Saitoh JI;Ebara T;Ohno T
肺癌是癌症相关死亡的主要原因。立体定向体部放疗（SBRT）是不可手术的早期非小细胞肺癌（NSCLC）的标准治疗。碳离子放射治疗（CIRT）是治疗早期NSCLC安全有效的方法。然而，这些治疗之间没有直接的比较研究。本研究旨在比较单一机构和同期队列中早期NSCLC接受CIRT和SBRT后的肿瘤学结局。我们对89例患者进行了对数秩检验和考克斯回归分析，结果表明CIRT组的总体生存率和局部控制率优于SBRT组。此外，这些结果在倾向评分调整分析中得到验证。本回顾性比较研究显示CIRT的积极疗效特征，这有利于早期NSCLC的管理。肺癌是全球癌症相关死亡的主要原因。放射治疗是不可手术的非小细胞肺癌（NSCLC）的基本治疗方式。立体定向体部放疗（SBRT）是早期NSCLC的标准治疗，因为与常规放疗相比，其具有良好的局部控制（LC）。碳离子放射治疗（CIRT）是一种外照射放射治疗，具有剂量分布陡、生物学效应高等特点。一些前瞻性研究显示了有利的结果。然而，CIRT和SBRT之间没有直接的比较研究来确定它们在早期NSCLC管理中的益处。因此，我们进行了一项回顾性、单一机构和同期比较研究，包括倾向评分调整分析，以澄清肿瘤结局的差异。CIRT和SBRT的3年总生存率（OS）分别为80.1%和71.6%（p = 0.0077）。CIRT组的3年LC为87.7%，SBRT组为79.1%（p = 0.037）。多变量分析显示CIRT组的OS和LC有利（危害风险[HR] = 0.41，p = 0.047; HR = 0.30，p = 0.040）。倾向评分匹配后的对数秩检验和使用倾向评分的考克斯回归分析证实了这些结果。这些数据提供了CIRT治疗早期NSCLC的积极疗效特征。
Lung cancer is a leading cause of cancer-related death. Stereotactic body radiotherapy (SBRT) is the standard treatment for inoperable early-stage non-small cell lung cancer (NSCLC). Carbon ion radiotherapy (CIRT) is a safe and effective treatment for early-stage NSCLC. However, there is no direct comparison study between these treatments. The present study aimed to compare oncologic outcomes after CIRT and SBRT for early-stage NSCLC in a single-institutional and contemporaneous cohort. We demonstrated favorable overall survival and local control in the CIRT group compared to those in the SBRT group using log-rank tests and Cox regression analyses for 89 patients. In addition, these results were validated in propensity score-adjusted analyses. The present retrospective comparison study showed a positive efficacy profile of CIRT, which is beneficial in the management of early-stage NSCLC. Lung cancer is a leading cause of cancer-related deaths worldwide. Radiotherapy is an essential treatment modality for inoperable non-small cell lung cancer (NSCLC). Stereotactic body radiotherapy (SBRT) is the standard treatment for early-stage NSCLC because of its favorable local control (LC) compared to conventional radiotherapy. Carbon ion radiotherapy (CIRT) is a kind of external beam radiotherapy characterized by a steeper dose distribution and higher biological effectiveness. Several prospective studies have shown favorable outcomes. However, there is no direct comparison study between CIRT and SBRT to determine their benefits in the management of early-stage NSCLC. Thus, we conducted a retrospective, single-institutional, and contemporaneous comparison study, including propensity score-adjusted analyses, to clarify the differences in oncologic outcomes. The 3-year overall survival (OS) was 80.1% in CIRT and 71.6% in SBRT (p = 0.0077). The 3-year LC was 87.7% in the CIRT group and 79.1% in the SBRT group (p = 0.037). Multivariable analyses showed favorable OS and LC in the CIRT group (hazard risk [HR] = 0.41, p = 0.047; HR = 0.30, p = 0.040, respectively). Log-rank tests after propensity score matching and Cox regression analyses using propensity score confirmed these results. These data provided a positive efficacy profile of CIRT for early-stage NSCLC.
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影响因子：
3.7
作者：
Shirai K;Kawashima M;Saitoh JI;Abe T;Fukata K;Shigeta Y;Irie D;Shiba S;Okano N;Ohno T;Nakano T
通讯作者：
Nakano T
DOI：
10.1016/j.ijrobp.2015.11.034
发表时间：
2016-05-01
影响因子：
7
作者：
Karube, Masataka;Yamamoto, Naoyoshi;Kamada, Tadashi
通讯作者：
Kamada, Tadashi
影响因子：
51.1
作者：
Chang, Joe Y.;Senan, Suresh;Paul, Marinus A.;Mehran, Reza J.;Louie, Alexander V.;Balter, Peter;Groen, Harry J. M.;McRae, Stephen E.;Widder, Joachim;Feng, Lei;van den Borne, Ben E. E. M.;Munsell, Mark F.;Hurkmans, Coen;Berry, Donald A.;van Werkhoven, Erik;Kresl, John J.;Dingemans, Anne-Marie;Dawood, Omar;Haasbeek, Cornelis J. A.;Carpenter, Larry S.;De Jaeger, Katrien;Komaki, Ritsuko;Slotman, Ben J.;Smit, Egbert F.;Roth, Jack A.
通讯作者：
Roth, Jack A.
影响因子：
5.7
作者：
Koto, M;Miyamoto, T;Tsujii, H
通讯作者：
Tsujii, H
DOI：
10.1016/j.ijrobp.2006.10.006
发表时间：
2007-03-01
影响因子：
7
作者：
Miyamoto, Tadaaki;Baba, Masayuki;Fujisawa, Takehiko
通讯作者：
Fujisawa, Takehiko