TMS enhances retention of a motor skill in Parkinson's disease.
TMS enhances retention of a motor skill in Parkinson's disease.
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DOI：
10.1016/j.brs.2014.11.005
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发表时间：
2015-03
影响因子：
7.7
通讯作者：
Sensory Motor Integration Lab (SMILab)
中科院分区：
文献类型：
--
作者：
Moisello C;Blanco D;Fontanesi C;Lin J;Biagioni M;Kumar P;Brys M;Loggini A;Marinelli L;Abbruzzese G;Quartarone A;Tononi G;Di Rocco A;Ghilardi MF;Sensory Motor Integration Lab (SMILab)
在帕金森氏病（PD）中，即使习得率一般保持，技能保留率也很差。最近对正常人的研究表明，5hz重复经颅磁刺激（5Hz-rTMS）可能在皮层水平上诱发长期增强现象。因此，我们验证了5Hz-rTMS是否能增强PD患者的视觉-运动技能的保留，这涉及到右侧后顶叶皮层的活动。一组PD患者进行了为期两天的测试，间隔一周（治疗和安慰剂组）。在每个疗程的第一天，他们学会了调整自己的动作以适应60°视觉旋转。任务完成后，在右侧后顶叶皮层（P6）上施加真实的5Hz-rTMS（治疗）或假的（安慰剂）刺激。第二天测试了这项运动技能的保留情况。在PD患者中，训练结束时获得的适应性与治疗组和安慰剂组相当，与一组年龄匹配的对照组相似。然而，与保留指数恢复到对照组水平的治疗阶段相比，安慰剂组在第二天测试的保留指数显着降低。重要的是，在治疗组和安慰剂组中，反应和运动时间以及其他运动学指标是相同的。这些结果表明，在获得运动技能后，在涉及该过程的特定区域应用rTMS可能会增强PD的技能保留。
In Parkinson’s disease (PD), skill retention is poor, even when acquisition rate is generally preserved. Recent work in normal subjects suggests that 5 Hz-repetitive transcranial magnetic stimulation (5Hz-rTMS) may induce phenomena of long-term potentiation at the cortical level. We thus verified whether, in PD, 5Hz-rTMS enhances retention of a visuo-motor skill that involves the activity of the right posterior parietal cortex. A group of patients with PD was tested in two two-day sessions, separated by one week (treatment and placebo sessions). The first day of each session, they learned to adapt their movements to a step-wise 60° visual rotation. Immediately after the task, either real 5Hz-rTMS (treatment) or sham (placebo) stimulation was applied over the right posterior parietal cortex (P6). Retention of this motor skill was tested the following day. In patients with PD, adaptation achieved at the end of training was comparable in the treatment and placebo sessions and was similar to that of a group of age-matched controls. However, retention indices tested on the following day were significantly lower in the placebo compared to the treatment session in which retention indices were restored to the level of the controls. Importantly, reaction and movement time as well as other kinematic measures were the same in the treatment and placebo sessions. These results suggest that rTMS applied after the acquisition of a motor skill over specific areas involved in this process might enhance skill retention in PD.
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DOI：
10.1016/j.clinph.2011.05.001
发表时间：
2011-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Landsness EC;Ferrarelli F;Sarasso S;Goldstein MR;Riedner BA;Cirelli C;Perfetti B;Moisello C;Ghilardi MF;Tononi G
通讯作者：
Tononi G
影响因子：
3.7
作者：
Huber R;Esser SK;Ferrarelli F;Massimini M;Peterson MJ;Tononi G
通讯作者：
Tononi G
影响因子：
14.5
作者：
Morgante, F;Espay, AJ;Chen, R
通讯作者：
Chen, R
影响因子：
5.5
作者：
Quartarone, Angelo;Rizzo, Vincenzo;Siebner, Hartwig Roman
通讯作者：
Siebner, Hartwig Roman
影响因子：
9.9
作者：
Siebner, HR;Peller, M;Bartenstein, P
通讯作者：
Bartenstein, P