Endocannabinoid signaling in the etiology and treatment of major depressive illness.
Endocannabinoid signaling in the etiology and treatment of major depressive illness.
复制标题
DOI：
10.2174/13816128113196660735
复制
发表时间：
2014
影响因子：
3.1
通讯作者：
Liu QS
中科院分区：
文献类型：
--
作者：
Hillard CJ;Liu QS
The purpose of this review is to examine human and preclinical data that are relevant to the following hypotheses. The first hypothesis is that deficient CB1R-mediated signaling results in symptoms that mimic those seen in depression. The second hypothesis is that activation of CB1R-mediated signaling results in behavioral, endocrine and other effects that are similar to those produced by currently used antidepressants. The third hypothesis is that conventional antidepressant therapies act through enhanced CB1R mediated signaling. Together the available data indicate that activators of CB1R signaling, particularly inhibitors of fatty acid amide hydrolase, should be considered for clinical trials for the treatment of depression.
登录
查看更多内容
影响因子：
10.6
作者：
Autry, Anita E.;Adachi, Megumi;Cheng, Pengfei;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
7.6
作者：
Bambico, Francis Rodriguez;Cassano, Tommaso;Gobbi, Gabriella
通讯作者：
Gobbi, Gabriella
影响因子：
2.8
作者：
Barrero, FJ;Ampuero, I;Yébenes, JG
通讯作者：
Yébenes, JG
影响因子：
4.7
作者：
Aso, Ester;Ozaita, Andres;Valverde, Olga
通讯作者：
Valverde, Olga
影响因子：
17.7
作者：
Bovasso, GB
通讯作者：
Bovasso, GB