Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior.
Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior.
复制标题
DOI：
10.1016/j.biopsych.2009.02.007
复制
发表时间：
2009-07-01
影响因子：
10.6
通讯作者：
Monteggia, Lisa M.
中科院分区：
文献类型：
--
作者：
Autry, Anita E.;Adachi, Megumi;Cheng, Pengfei;Monteggia, Lisa M.
重度抑郁症是一种主要的使人衰弱的疾病，已知女性发病率是男性的两倍。抑郁症的神经营养假说认为，脑源性神经营养因子（BDNF）的缺失可能会增加患抑郁症样行为的易感性，尽管缺乏直接证据。
利用慢性不可预测应激范式（CUS），我们研究了前脑可诱导性BDNF缺失的雄性和雌性小鼠是否更容易出现与抑郁症相关的行为。
我们证明，在某些行为指标上，与野生型雌性相比，在整个发情期随机研究的雌性小鼠中，BDNF的缺失降低了其在慢性应激后表现出焦虑和快感缺失行为的阈值。然而，前脑BDNF的缺失并不会增加雄性小鼠患抑郁症样行为的易感性。
这些性别差异表明BDNF在介导雌性抑郁症相关行为的某些方面起作用。
Major depressive disorder is a leading debilitating disease known to occur at a two-fold higher rate in women than in men. The neurotrophic hypothesis of depression suggests that loss of brain-derived neurotrophic factor (BDNF) may increase susceptibility for depression-like behavior, although direct evidence is lacking. Using the chronic unpredictable stress paradigm (CUS), we investigated whether male and female mice with inducible BDNF deletion in the forebrain were more susceptible to depression-related behavior. We demonstrate that in certain behavioral measures the loss of BDNF lowers the threshold for females studied at random throughout estrus to display anxiogenic and anhedonic behaviors after chronic stress compared to wild type females. However, the loss of BDNF in forebrain does not increase the susceptibility to depression-like behavior in males. These gender differences suggest a role for BDNF in mediating some aspects of depression-related behavior in females.
登录
查看更多内容
影响因子：
4.7
作者：
Bezchlibnyk, YB;Wang, JF;Young, LT
通讯作者：
Young, LT
影响因子：
2.7
作者：
Mineur, Yann S.;Belzung, Catherine;Crusio, Wim E.
通讯作者：
Crusio, Wim E.
影响因子：
5.2
作者：
Gourley SL;Wu FJ;Taylor JR
通讯作者：
Taylor JR
影响因子：
10.6
作者：
Liu, XQ;Gershenfeld, HK
通讯作者：
Gershenfeld, HK
DOI：
10.1073/pnas.172091899
发表时间：
2002-08-20
影响因子：
11.1
作者：
Barrot, M;Olivier, JDA;Nestler, EJ
通讯作者：
Nestler, EJ