Skeletal muscle function underpins muscle spindle abundance.
Skeletal muscle function underpins muscle spindle abundance.
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DOI：
10.1098/rspb.2022.0622
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发表时间：
2022-06-08
影响因子：
4.7
通讯作者：
Bates, Karl T.
中科院分区：
文献类型：
--
作者：
Kissane, Roger W. P.;Charles, James P.;Banks, Robert W.;Bates, Karl T.
肌梭的丰度在物种内和物种之间是高度不同的，但我们目前缺乏任何关于这种差异的机制原因或后果的清晰图景。以前使用纺锤体丰度作为肌肉功能的相关性暗示了这种变异的机械支持，但这些想法还没有得到检验。在这里，我们使用集成的医学成像和特定对象的肌肉骨骼模型来研究人体运动系统中纺锤体丰度、肌肉结构和活体肌肉行为之间的关系。这些分析表明，肌梭数与肌束长度、肌束绝对长度变化、肌纤维延长速度和步行时的主动肌力密切相关。功能指数和心轴丰度之间的新关联也被恢复，其中高丰度的肌肉主要起到弹簧的作用，而低丰度的肌肉在行走时主要起刹车的作用。这些数据表明，肌肉纤维长度、延长速度和纤维力是中枢神经系统及其运动调节的关键生理信号，肌梭丰富程度可能与肌肉如何产生功密切相关。这些见解可能与神经力学和机器人对运动控制的研究相结合，以帮助进一步梳理肌梭组成的功能驱动因素。
Muscle spindle abundance is highly variable within and across species, but we currently lack any clear picture of the mechanistic causes or consequences of this variation. Previous use of spindle abundance as a correlate for muscle function implies a mechanical underpinning to this variation, but these ideas have not been tested. Herein, we use integrated medical imaging and subject-specific musculoskeletal models to investigate the relationship between spindle abundance, muscle architecture and in vivo muscle behaviour in the human locomotor system. These analyses indicate that muscle spindle number is tightly correlated with muscle fascicle length, absolute fascicle length change, velocity of fibre lengthening and active muscle forces during walking. Novel correlations between functional indices and spindle abundance are also recovered, where muscles with a high abundance predominantly function as springs, compared to those with a lower abundance mostly functioning as brakes during walking. These data demonstrate that muscle fibre length, lengthening velocity and fibre force are key physiological signals to the central nervous system and its modulation of locomotion, and that muscle spindle abundance may be tightly correlated to how a muscle generates work. These insights may be combined with neuromechanics and robotic studies of motor control to help further tease apart the functional drivers of muscle spindle composition.
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