Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions.
Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions.
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DOI：
10.3389/fphys.2018.00784
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发表时间：
2018
影响因子：
4
通讯作者：
Knikou M
中科院分区：
文献类型：
--
作者：
Côté MP;Murray LM;Knikou M
对脊髓中间神经元的生理和解剖特征沿着功能输出的系统研究已经发展了一个多世纪。尽管我们对这些网络及其在产生和调节运动中的作用的理解取得了重大进展，但阐明跨物种运动节律的特性仍然是一个挑战。神经生理学实验证据表明，中间神经元介导有关肌肉拉伸和负荷的传入信息的功能相似，受到运动轴突侧支的影响，以及在动物和人类中介导突触前抑制的功能相似。然而，在跨物种的运动过程中观察到显着不同的肌肉激活配置文件。这种差异可能是由人类多个节段水平的肌肉传入神经分布改变所驱动的，从而导致不同类别的脊髓中间神经元之间的相互作用改变。此外，在所有物种中，不同类型的脊髓中间神经元可能在某种程度上同时被激活或沉默。不管这些限制，在哺乳动物运动过程中的脊髓神经元间回路的功能上的持续努力将有助于描绘运动控制的神经机制，并有助于在人类双足步态受损的情况下开发新的有针对性的康复策略。这些康复策略将包括基于活动的治疗和通过向大脑和/或脊髓传递重复刺激的脊髓神经元间回路的靶向神经调节。
Systematic research on the physiological and anatomical characteristics of spinal cord interneurons along with their functional output has evolved for more than one century. Despite significant progress in our understanding of these networks and their role in generating and modulating movement, it has remained a challenge to elucidate the properties of the locomotor rhythm across species. Neurophysiological experimental evidence indicates similarities in the function of interneurons mediating afferent information regarding muscle stretch and loading, being affected by motor axon collaterals and those mediating presynaptic inhibition in animals and humans when their function is assessed at rest. However, significantly different muscle activation profiles are observed during locomotion across species. This difference may potentially be driven by a modified distribution of muscle afferents at multiple segmental levels in humans, resulting in an altered interaction between different classes of spinal interneurons. Further, different classes of spinal interneurons are likely activated or silent to some extent simultaneously in all species. Regardless of these limitations, continuous efforts on the function of spinal interneuronal circuits during mammalian locomotion will assist in delineating the neural mechanisms underlying locomotor control, and help develop novel targeted rehabilitation strategies in cases of impaired bipedal gait in humans. These rehabilitation strategies will include activity-based therapies and targeted neuromodulation of spinal interneuronal circuits via repetitive stimulation delivered to the brain and/or spinal cord.
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影响因子：
5.5
作者：
BERARDELLI, A;DAY, BL;ROTHWELL, JC
通讯作者：
ROTHWELL, JC
影响因子：
2
作者：
ALSTERMARK, B;KUMMEL, H
通讯作者：
KUMMEL, H
影响因子：
5.5
作者：
Bautista, Wendy;Nagy, James I.;McCrea, David A.
通讯作者：
McCrea, David A.
影响因子：
64.8
作者：
Andersson, Lisa S.;Larhammar, Martin;Memic, Fatima;Wootz, Hanna;Schwochow, Doreen;Rubin, Carl-Johan;Patra, Kalicharan;Arnason, Thorvaldur;Wellbring, Lisbeth;Hjalm, Goran;Imsland, Freyja;Petersen, Jessica L.;McCue, Molly E.;Mickelson, James R.;Cothran, Gus;Ahituv, Nadav;Roepstorff, Lars;Mikko, Sofia;Vallstedt, Anna;Lindgren, Gabriella;Andersson, Leif;Kullander, Klas
通讯作者：
Kullander, Klas
DOI：
10.1111/j.1748-1716.1983.tb07267.x
发表时间：
1983-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
ANDERSSON, O;GRILLNER, S
通讯作者：
GRILLNER, S