Post-Acute COVID-19 Syndrome and the cardiovascular system: What is known?
Post-Acute COVID-19 Syndrome and the cardiovascular system: What is known?
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DOI：
10.1016/j.ahjo.2021.100025
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Hsu JJ
中科院分区：
文献类型：
--
作者：
Dixit NM;Churchill A;Nsair A;Hsu JJ
急性COVID-19后综合征（PACS）是指COVID-19发病后3-4周内持续出现的症状。这些持续症状的机制与急性COVID-19不同，尽管PACS的发病率很高，但尚未完全了解。心血管症状，如胸痛和心悸，通常发生在PACS中，但症状的根本原因是不常见的。虽然尸检研究表明，严重急性呼吸综合征冠状病毒-2（SARS-CoV-2）很少引起直接心肌损伤，但PACS涉及心肌炎、心包炎和体位性心动过速综合征等几种综合征。此外，显示心肌损伤生物标志物证据的急性COVID-19住院患者可能患有SARS-CoV-2感染的生理应激所揭示的潜在冠状动脉疾病，并可能受益于医疗优化。我们回顾了PACS和心血管系统的已知信息，并提出了一个评估和管理相关症状的框架。
Post-Acute COVID-19 Syndrome (PACS) is defined by persistent symptoms >3–4 weeks after onset of COVID-19. The mechanism of these persistent symptoms is distinct from acute COVID-19 although not completely understood despite the high incidence of PACS. Cardiovascular symptoms such as chest pain and palpitations commonly occur in PACS, but the underlying cause of symptoms is infrequently known. While autopsy studies have shown that the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) rarely causes direct myocardial injury, several syndromes such as myocarditis, pericarditis, and Postural Orthostatic Tachycardia Syndrome have been implicated in PACS. Additionally, patients hospitalized with acute COVID-19 who display biomarker evidence of myocardial injury may have underlying coronary artery disease revealed by the physiological stress of SARS-CoV-2 infection and may benefit from medical optimization. We review what is known about PACS and the cardiovascular system and propose a framework for evaluation and management of related symptoms.
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