Cardiovascular correlates of motor vehicle accident related posttraumatic stress disorder and its successful treatment.
Cardiovascular correlates of motor vehicle accident related posttraumatic stress disorder and its successful treatment.
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DOI：
10.1007/s10484-006-9027-1
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发表时间：
2006-12
影响因子：
3
通讯作者：
Karl, Anke
中科院分区：
文献类型：
--
作者：
Rabe, Sirko;Doerfel, Denise;Zoellner, Tanja;Maercker, Andreas;Karl, Anke
患有创伤后应激障碍（PTSD）的人表现出基线心血管活动升高和对创伤相关刺激的生理反应增强。研究1检查了68名机动车事故（MVA）幸存者和无MVA的健康对照者的基线心率（HR）和HR反应性的差异。MVA幸存者PTSD（n=26），亚综合征PTSD（n=22），创伤对照无PTSD（非PTSD与MVA，n=20）和健康对照无MVA（HC，n=27）进行了测量HR在基线和暴露于中性，积极，消极，创伤相关的图片。PTSD患者仅在暴露于创伤相关图片期间表现出基线HR升高和HR反应性增加。研究2调查了在研究1中观察到的升高的生理反应在认知行为治疗（CBT）后是否正常化。我们进行了一项随机对照治疗试验，将CBT（n=17）与Wait-list条件（WLC，n=18）进行比较。结果显示，CBT的HR反应性下降幅度大于WLC。HR反应性的变化与临床改善相关。
Persons with posttraumatic stress disorder (PTSD) have been shown to display elevated baseline cardiovascular activity and a heightened physiological reactivity to trauma-related stimuli. Study 1 examined differences in baseline heart rate (HR) and HR reactivity in 68 survivors of motor vehicle accidents (MVAs) and healthy controls without MVA. MVA survivors with PTSD (n=26), subsyndromal PTSD (n=22), traumatized controls without PTSD (non-PTSD with MVA, n=20) and healthy controls without MVA (HC, n=27) underwent measurement of HR during baseline and exposure to a neutral, positive, negative, and trauma-related picture. PTSD patients showed elevated baseline HR and increased HR reactivity only during exposure to the trauma-related picture. Study 2 investigated whether the elevated physiological responses observed in Study 1 normalized after cognitive behavioral therapy (CBT). We conducted a randomized, controlled treatment trial comparing CBT (n=17) to a Wait-list condition (WLC, n=18). Results showed a greater decrease in HR reactivity for CBT than for WLC. The change in HR reactivity was associated with clinical improvement.
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