Physiological functions of MTA family of proteins.
Physiological functions of MTA family of proteins.
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DOI：
10.1007/s10555-014-9514-4
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发表时间：
2014-12
影响因子：
9.2
通讯作者：
Kumar, Rakesh
中科院分区：
文献类型：
--
作者：
Sen, Nirmalya;Gui, Bin;Kumar, Rakesh
虽然MTA家族的染色质重塑蛋白在癌症的病理生物学中的功能意义是相当好的认识，MTA蛋白的生理作用仍然是一个未充分研究的研究领域，并且刚刚开始被认识。与癌细胞类似，MTA 1也通过作为辅阻遏物或辅激活物来调节正常细胞中靶基因的表达。此外，MTA蛋白的生理功能可能受到其差异表达、亚细胞定位以及上游调节剂和细胞外信号的调节的影响。本文综述了MTA蛋白在模型系统中的生理功能。特别是，我们强调MTA蛋白在大脑，眼睛，昼夜节律，乳腺生物学，精子发生，肝脏，免疫调节和炎症，细胞放射敏感性，造血和分化中发挥的作用的最新进展。基于有关MTA家族蛋白质在生物学和医学中令人兴奋的新方面的知识的增长，我们推测，该领域的下一个发现可能会揭示MTA辅助调节因子在正常生理学和癌症以外的病理条件下的非冗余功能的进一步分子调控见解。
Although the functional significance of the MTA family of chromatin remodeling proteins in the pathobiology of cancer is fairly well recognized, the physiological role of MTA proteins continues to be an understudied research area and is just beginning to be recognized. Similar to cancer cells, MTA1 also modulates the expression of target genes in normal cells either by acting as a corepressor or coactivator. In addition, physiological functions of MTA proteins are likely to be influenced by its differential expression, subcellular localization and regulation by upstream modulators and extracellular signals. This review summarizes our current understanding of physiological functions of the MTA proteins in model systems. In particular, we highlight recent advances of the role MTA proteins play in the brain, eye, circadian rhythm, mammary gland biology, spermatogenesis, liver, immunomodulation and inflammation, cellular radio-sensitivity, and hematopoiesis and differentiation. Based on the growth of knowledge regarding the exciting new facets of the MTA family of proteins in biology and medicine, we speculate that the next burst of findings in this field may reveal further molecular regulatory insights of non-redundant functions of MTA coregulators in the normal physiology as well as in pathological conditions outside cancer.
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