Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia.
Body Composition, IGF1 Status, and Physical Functionality in Nonagenarians: Implications for Osteosarcopenia.
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DOI：
10.1016/j.jamda.2018.07.007
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发表时间：
2019-01
影响因子：
7.6
通讯作者：
Ravussin E
中科院分区：
文献类型：
--
作者：
Poggiogalle E;Cherry KE;Su LJ;Kim S;Myers L;Welsh DA;Jazwinski SM;Ravussin E
身体组成的改变发生在衰老过程中。本分析的目的是探讨肌肉减少症和骨质疏松症重叠的功能后果，以及胰岛素样生长因子1（IGF 1）在老年人发展中的潜在作用。87名来自路易斯安那州健康老龄化研究的90岁以上老人被纳入其中。肌肉减少症的定义是基于非典型瘦体重（ALM）。根据骨密度（BMD）T评分诊断骨质疏松症。比较了四种表型：（1）健康的身体组成，即，非骨质疏松性非肌肉减少性（CO，对照组），（2）骨质疏松性（O，低BMD T评分），（3）肌肉减少性（S，低ALM），和（4）骨质疏松性（OS，低BMD T评分和低ALM）。计算性别和年龄特异性IGF 1标准差评分（SDS）。进行了连续Scalee物理功能性能（CS-PFP）测试。在OS男性中，IGF 1-SDS值（−0.61 ±0.37 vs −0.04 ± 0.52，P = 0.02）低于CO男性（对照组），而女性的4种身体组成表型的IGF 1-SDS相似。仅在男性中，ALM与IGF 1-SDS值呈正相关（P = 0.01），与年龄和C反应蛋白浓度无关。关于骨骼健康，我们发现IGF 1-SDS值和BMD之间没有关联。IGF 1-SDS与男性和女性的功能表现（CS-PFP）无关。骨骼肌和骨骼中IGF 1的敏感性可能因性别而异。IGF 1状态似乎不影响身体功能。决定因素和临床和功能特点的骨减少症需要进一步调查，以确定结论性的诊断标准。
Body composition alterations occur during aging. The purpose of the present analysis was to explore the functional consequences of the overlap of sarcopenia and osteoporosis, and the potential role of insulin-like growth factor 1 (IGF1) in their development in the oldest old. Eighty-seven nonagenarians from the Louisiana Healthy Aging Study were included. The definition of sarcopenia was based on appendicular lean mass (ALM). Osteoporosis was diagnosed based on bone mineral density (BMD) T score. Four phenotypes were compared: (1) healthy body composition, that is, nonosteoporotic nonsarcopenic (CO, control group), (2) osteoporotic (O, low BMD T score), (3) sarcopenic (S, low ALM), and (4) osteosarcopenic (OS, low BMD T score and low ALM). Sex- and age-specific IGF1-Standard Deviation Scores (SDS) were calculated. The Continuous Scalee Physical Functional Performance (CS-PFP) test was performed. In OS men, IGF1-SDS values (−0.61 ±0.37 vs −0.04 ± 0.52, P = .02) were lower than those in CO males (control group), whereas IGF1-SDS were similar in the 4 body composition phenotypes in women. In men only, ALM was positively associated with IGF1-SDS values (P = .01) independent of age and C-reactive protein concentration. Regarding bone health, we found no association between IGF1-SDS values and BMD. IGF1-SDS was not associated with functional performance (CS-PFP) in men and women. IGF1 sensitivity in skeletal muscle and bone may differ by sex in the oldest old. IGF1 status did not appear to affect physical functionality. Determinants and clinical and functional characteristics of osteosarcopenia need to be further investigated in order to define conclusive diagnostic criteria.
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DOI：
10.1093/gerona/glu023
发表时间：
2014-05-01
影响因子：
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作者：
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DOI：
10.1093/gerona/62.7.783
发表时间：
2007-07-01
影响因子：
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