Green and Cost-Effective Synthesis of Metallic Nanoparticles by Algae: Safe Methods for Translational Medicine.
Green and Cost-Effective Synthesis of Metallic Nanoparticles by Algae: Safe Methods for Translational Medicine.
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DOI：
10.3390/bioengineering7040129
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发表时间：
2020-10-16
期刊：
影响因子：
--
通讯作者：
Menaa F
中科院分区：
文献类型：
--
作者：
Uzair B;Liaqat A;Iqbal H;Menaa B;Razzaq A;Thiripuranathar G;Fatima Rana N;Menaa F
金属纳米颗粒(NPs)因其独特的化学、电学、催化和光学性质，如表面等离子体共振(SPR)效应，在医学(主要是肿瘤学、放射学和感染学)中的潜在应用引起了人们的极大关注。它们还易于受控合成和表面修饰(例如，封端/保护剂包括N-、P-、COOH-、SH-分子和硫醇、二硫化物、铵、胺和多齿羧酸盐聚合物所赋予的量身定制的性能)，从而允许(I)调整它们的大小和形状(例如，星形和/或支化)，(Ii)提高它们的稳定性、单分散性、化学相容性和活性，(Iii)避免它们随着时间的推移而聚集和氧化，(Iv)提高它们的产率和纯度。与自上而下的方法相比，自下而上的方法已经得到了广泛的应用。在这种方法中，金属离子在覆盖配体的存在下生长的纳米粒子中被还原。除了物理和化学合成方法外，生物法也越来越受到人们的重视。事实上，已经报道了通过物理方法(例如，辐射、超声波)和化学方法(例如，电化学、用诸如柠檬酸三钠或抗坏血酸等化学物质进行还原)来合成纳米粒子的几个缺点(例如，成本，和/或由于使用危险溶剂、低产量、使用大量能源而造成的毒性)。然而，(有机或无机)生态友好型纳米粒子的合成展示了一种可持续、安全和经济的解决方案。因此，人们观察到了从(活的或死的)藻类(即微藻、巨藻和蓝藻)快速而有价值地合成NPs的相对新的趋势，特别是因为它在地壳中的大量存在以及它们的独特性质(例如，积累和还原金属离子的能力，快速繁殖)。本文讨论了藻类介导的无机纳米粒子的合成方法(无论是细胞内还是细胞外)，特别是最贵重的金属，即银(Ag)和金(Au)来源的纳米粒子。重点介绍了影响其生物合成过程、稳定性、大小和形状的关键因素(如pH、温度、反应时间)。最后，介绍了这些藻类纳米颗粒的潜在分子机制、纳米毒性和主要生物医学应用实例。
Metal nanoparticles (NPs) have received much attention for potential applications in medicine (mainly in oncology, radiology and infectiology), due to their intriguing chemical, electronical, catalytical, and optical properties such as surface plasmon resonance (SPR) effect. They also offer ease in controlled synthesis and surface modification (e.g., tailored properties conferred by capping/protecting agents including N-, P-, COOH-, SH-containing molecules and polymers such as thiol, disulfide, ammonium, amine, and multidentate carboxylate), which allows (i) tuning their size and shape (e.g., star-shaped and/or branched) (ii) improving their stability, monodispersity, chemical miscibility, and activity, (iii) avoiding their aggregation and oxidation over time, (iv) increasing their yield and purity. The bottom-up approach, where the metal ions are reduced in the NPs grown in the presence of capping ligands, has been widely used compared to the top-down approach. Besides the physical and chemical synthesis methods, the biological method is gaining much consideration. Indeed, several drawbacks have been reported for the synthesis of NPs via physical (e.g., irradiation, ultrasonication) and chemical (e.g., electrochemisty, reduction by chemicals such as trisodium citrate or ascorbic acid) methods (e.g., cost, and/ortoxicity due to use of hazardous solvents, low production rate, use of huge amount of energy). However, (organic or inorganic) eco-friendly NPs synthesis exhibits a sustainable, safe, and economical solution. Thereby, a relatively new trend for fast and valuable NPs synthesis from (live or dead) algae (i.e., microalgae, macroalgae and cyanobacteria) has been observed, especially because of its massive presence on the Earth’s crust and their unique properties (e.g., capacity to accumulate and reduce metallic ions, fast propagation). This article discusses the algal-mediated synthesis methods (either intracellularly or extracellularly) of inorganic NPs with special emphasis on the noblest metals, i.e., silver (Ag)- and gold (Au)-derived NPs. The key factors (e.g., pH, temperature, reaction time) that affect their biosynthesis process, stability, size, and shape are highlighted. Eventually, underlying molecular mechanisms, nanotoxicity and examples of major biomedical applications of these algal-derived NPs are presented.
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DOI：
10.3390/ma6125942
发表时间：
2013-12-18
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Azizi S;Namvar F;Mahdavi M;Ahmad MB;Mohamad R
通讯作者：
Mohamad R
影响因子：
3.3
作者：
Belay, A;Kato, T;Ota, Y
通讯作者：
Ota, Y
影响因子：
3.5
作者：
Coradeghini, Rosella;Gioria, Sabrina;Rossi, Francois
通讯作者：
Rossi, Francois
影响因子：
5.4
作者：
Ali L;Khan AL;Al-Broumi M;Al-Harrasi R;Al-Kharusi L;Hussain J;Al-Harrasi A
通讯作者：
Al-Harrasi A
影响因子：
7.1
作者：
Bhatnagar, Ashish;Gupta, Bipin Kumar;Srivastava, Onkar Nath
通讯作者：
Srivastava, Onkar Nath