Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels.
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels.
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DOI：
10.1038/ncomms1786
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发表时间：
2012-04-17
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
放射治疗后经常发生肿瘤复发，但放射抗性癌细胞的特征、肿瘤内定位和放射后行为仍然很大程度上未知。在这里，我们开发了一个复杂的策略来跟踪辐射后的细胞，在辐射时存在于周围坏死区的命运。尽管围坏死肿瘤细胞最初是缺氧诱导因子1（HIF-1）阴性的，但它们在存活的辐射后获得HIF-1活性，这触发它们向肿瘤血管的易位。HIF-1抑制剂可抑制这种易位并降低放射后肿瘤复发的发生率。我们的数据首次揭示了照射后肿瘤复发过程中HIF-1依赖的细胞动力学，并为放射治疗后靶向HIF-1提供了合理的基础。放射疗法用于治疗许多癌症，但耐辐射细胞可导致肿瘤复发。在这里，Harada及其同事开发了一种方法来跟踪放射治疗后持续存在的细胞，并显示细胞获得HIF-1的转录活性并向血管移动。
Tumour recurrence frequently occurs after radiotherapy, but the characteristics, intratumoural localization and post-irradiation behaviour of radioresistant cancer cells remain largely unknown. Here we develop a sophisticated strategy to track the post-irradiation fate of the cells, which exist in perinecrotic regions at the time of radiation. Although the perinecrotic tumour cells are originally hypoxia-inducible factor 1 (HIF-1)-negative, they acquire HIF-1 activity after surviving radiation, which triggers their translocation towards tumour blood vessels. HIF-1 inhibitors suppress the translocation and decrease the incidence of post-irradiation tumour recurrence. For the first time, our data unveil the HIF-1-dependent cellular dynamics during post-irradiation tumour recurrence and provide a rational basis for targeting HIF-1 after radiation therapy. Radiotherapy is used to treat many cancers but radiation-resistant cells can result in recurrence of the tumour. Here, Harada and colleagues develop a method to track cells that persist after radiation treatment and show that the cells acquire transcriptional activity of HIF-1 and move towards blood vessels.
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DOI：
10.1006/bbrc.1997.7124
发表时间：
1997-08-28
影响因子：
3.1
作者：
Feil, R;Wagner, J;Chambon, P
通讯作者：
Chambon, P
影响因子：
8.8
作者：
Harada, H.;Itasaka, S.;Zhu, Y.;Zeng, L.;Xie, X.;Morinibu, A.;Shinomiya, K.;Hiraoka, M.
通讯作者：
Hiraoka, M.
影响因子：
56.9
作者：
Jaakkola, P;Mole, DR;Ratcliffe, PJ
通讯作者：
Ratcliffe, PJ
影响因子：
14.9
作者：
Indra, AK;Warot, X;Metzger, D
通讯作者：
Metzger, D
影响因子：
3.4
作者：
DESCHNER, EE;GRAY, LH
通讯作者：
GRAY, LH