Progress in aminocyclitol biosynthesis.

Progress in aminocyclitol biosynthesis.
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DOI:
10.1016/j.cbpa.2009.02.030
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发表时间:
2009-04
影响因子:
7.8
通讯作者:
Mahmud, Taifo
Mahmud, Taifo
中科院分区:
生物学2区
文献类型:
--
作者:
Mahmud, Taifo

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在过去的几年中,氨基环醇生物合成的遗传和生化信息为研究这类重要的临床天然产物的形成模式提供了基础。除了对氨基环醇生物合成基因簇的鉴定和功能分析外,最近的一些研究还集中在对这些途径固有的独特酶和催化机制的详细分析上。这些结果为氨基环糖醇生物合成的生化和分子方面提供了宝贵的见解,并揭示了途径的多样性和独特性。
A stream of genetic and biochemical information available for the biosynthesis of aminocyclitols over the past few years has provided the foundation to study the modes of formation of this clinically important class of natural products. In addition to work on the identification and functional analysis of aminocyclitol biosynthetic gene clusters, a contingent of recent studies has focused on the detailed analysis of unique enzymatic and catalytic mechanisms inherent to these pathways. The results provide invaluable insights into the biochemical and molecular aspects of aminocyclitol biosynthesis and have revealed diverse and unique features of the pathways.
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