Novel copolyanhydrides combining strong inherent fluorescence and a wide range of biodegradability: synthesis, characterization and in vitro degradation.
Novel copolyanhydrides combining strong inherent fluorescence and a wide range of biodegradability: synthesis, characterization and in vitro degradation.
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新型共聚酸酐结合了强烈的固有荧光和广泛的生物降解性：合成、表征和体外降解。
DOI：
10.1002/mabi.200500014
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发表时间：
2005
影响因子：
4.6
通讯作者：
K. Zhu
中科院分区：
文献类型：
--
作者：
Hongliang Jiang;Dian Chen;Pengcheng Zhao;Y. Li;K. Zhu
在这项工作中，以非常方便的方案合成了一种新型二酸单体。该单体源自天然产物，聚合成聚酐时会发出强烈的荧光。单体dCPS的化学结构如下：HOC(O)ArOC(O)(CH2)2C(O)O--Ar--COOH。通过熔融共缩聚进一步制备了dCPS和癸二酸的共聚酸酐，并通过IR、NMR、UV-Vis、DSC和荧光法进行了表征。共聚物的发射波长(lambda(em))可以通过激发波长(lambda(ex))来调节。荧光强度随着dCPS含量的增加而增加。由 dCPS 含量低至 10% 的共聚物制成的微球可以通过荧光显微镜清晰地观察到。在紫外光和可见光的激发下，可以捕获微球的蓝色或绿色图像。随着dCPS分数的增加，共聚酸酐的降解速率降低，并且降解持续时间可以从几天调整到三个月以上。此外，还发现共聚酸酐表现出表面降解特性。鉴于新型共聚酸酐的优点，例如易于制备、独特的固有发光特性和可广泛调节的降解率，它们可能可用于生物医学工程。
In this work, a novel diacid monomer was synthesized in a very convenient scheme. The monomer is derived from naturally occurring products and emits strong fluorescence when polymerized to polyanhydride. The chemical structure of the monomer dCPS is as follows: HOC(O)ArOC(O)(CH2)2C(O)O--Ar--COOH. Copolyanhydrides composed of dCPS and sebacic acid were further prepared by melt copolycondensation, and characterized by IR, NMR, UV-Vis, DSC and fluorometry. The emission wavelength (lambda(em)) of the copolymers could be tuned by the excitation wavelength (lambda(ex)). Fluorescence intensity increased with the increase of dCPS content. The microspheres fabricated from the copolymer with dCPS content as low as 10% could be clearly visualized with fluorescence microscopy. Either blue or green images of the microspheres could be captured with an excitation of UV and visible light. The degradation rate of the copolyanhydrides decreased as the dCPS fraction increased, and the degradation duration could be modulated from several days to more than three months. In addition, it was found that the copolyanhydrides displayed surface degradation characteristics. In view of the advantages of the novel copolyanhydrides, such as easy preparation, unique inherent luminescent properties, and widely adjustable degradation rate, they might be useful for biomedical engineering.
影响因子：
5.8
作者：
Panyam, J;Sahoo, SK;Labhasetwar, V
通讯作者：
Labhasetwar, V
影响因子：
14
作者：
Burkoth, AK;Anseth, KS
通讯作者：
Anseth, KS
评估聚合物微球共混物中的酸酐低聚物及其对体外生物粘附和药物递送的影响。
影响因子：
14
作者：
Santos,CA;Freedman,BD;Ghosn,S;Jacob,JS;Scarpulla,M;Mathiowitz,E
通讯作者：
Mathiowitz,E