Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging.
Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging.
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DOI：
10.3390/antiox11020192
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发表时间：
2022-01-19
期刊：
影响因子：
--
通讯作者：
Bai H
中科院分区：
文献类型：
--
作者：
Kim J;Bai H
过氧化物酶体是细胞和代谢稳态的关键调节剂。这些细胞器在氧化还原代谢、极长链脂肪酸（VLCFAs）的氧化和醚磷脂的生物合成中起重要作用。鉴于过氧化物酶体在细胞内稳态中的重要作用，过氧化物酶体功能障碍与各种病理状况、组织功能下降和衰老有关。在过去的几十年中，各种细胞信号和代谢变化已被报道与有缺陷的过氧化物酶体有关，这表明许多细胞过程和功能依赖于过氧化物酶体。过氧化物酶体与其他亚细胞器，如细胞核，线粒体，内质网（ER）和溶酶体沟通。这些细胞器间的通信与细胞监视有缺陷的过氧化物酶体并启动适应性反应以保护它们免受损害的关键机制高度相关。在这篇综述中，我们强调了主要的细胞变化，伴随过氧化物酶体功能障碍和过氧化物酶体细胞器间的通信通过膜接触网站，代谢信号，和逆行信号。我们还讨论了与年龄相关的过氧化物酶体蛋白输入的下降及其在动物衰老和年龄相关疾病中的作用。与其他细胞器应激反应途径（如ER和线粒体中的未折叠蛋白反应（UPR））不同，介导对过氧化物酶体故障的应激反应的细胞信号传导途径尚未得到系统的研究和调查。在这里，我们将这些信号通路称为“过氧化物酶体应激反应通路”。了解过氧化物酶体应激反应途径以及过氧化物酶体如何与其他细胞器进行通信是过氧化物酶体研究的重要和新兴领域。
Peroxisomes are key regulators of cellular and metabolic homeostasis. These organelles play important roles in redox metabolism, the oxidation of very-long-chain fatty acids (VLCFAs), and the biosynthesis of ether phospholipids. Given the essential role of peroxisomes in cellular homeostasis, peroxisomal dysfunction has been linked to various pathological conditions, tissue functional decline, and aging. In the past few decades, a variety of cellular signaling and metabolic changes have been reported to be associated with defective peroxisomes, suggesting that many cellular processes and functions depend on peroxisomes. Peroxisomes communicate with other subcellular organelles, such as the nucleus, mitochondria, endoplasmic reticulum (ER), and lysosomes. These inter-organelle communications are highly linked to the key mechanisms by which cells surveil defective peroxisomes and mount adaptive responses to protect them from damages. In this review, we highlight the major cellular changes that accompany peroxisomal dysfunction and peroxisomal inter-organelle communication through membrane contact sites, metabolic signaling, and retrograde signaling. We also discuss the age-related decline of peroxisomal protein import and its role in animal aging and age-related diseases. Unlike other organelle stress response pathways, such as the unfolded protein response (UPR) in the ER and mitochondria, the cellular signaling pathways that mediate stress responses to malfunctioning peroxisomes have not been systematically studied and investigated. Here, we coin these signaling pathways as “peroxisomal stress response pathways”. Understanding peroxisomal stress response pathways and how peroxisomes communicate with other organelles are important and emerging areas of peroxisome research.
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影响因子：
6
作者：
Bonekamp, Nina A.;Voelkl, Alfred;Schrader, Michael
通讯作者：
Schrader, Michael
影响因子：
3.7
作者：
Astarita G;Jung KM;Berchtold NC;Nguyen VQ;Gillen DL;Head E;Cotman CW;Piomelli D
通讯作者：
Piomelli D
影响因子：
3.7
作者：
Brites P;Ferreira AS;da Silva TF;Sousa VF;Malheiro AR;Duran M;Waterham HR;Baes M;Wanders RJ
通讯作者：
Wanders RJ
影响因子：
16.6
作者：
Ciniawsky, Susanne;Grimm, Immanuel;Saffian, Delia;Girzalsky, Wolfgang;Erdmann, Ralf;Wendler, Petra
通讯作者：
Wendler, Petra
DOI：
10.1073/pnas.1500257112
发表时间：
2015-07-28
影响因子：
11.1
作者：
Blok, Neil B.;Tan, Dongyan;Walz, Thomas
通讯作者：
Walz, Thomas