Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
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DOI:
10.1039/b9pp00130a
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发表时间:
2010-04
期刊:
影响因子:
--
通讯作者:
Talalay P
中科院分区:
文献类型:
--
作者:
Dinkova-Kostova AT;Fahey JW;Benedict AL;Jenkins SN;Ye L;Wehage SL;Talalay P
Feeding broccoli sprout extracts providing daily doses of 10 μmol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm-2 of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.
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