Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
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DOI:
10.1039/b9pp00130a
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发表时间:
2010-04
期刊:
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
影响因子:
--
通讯作者:
Talalay P
Talalay P
中科院分区:
其他
文献类型:
--
作者:
Dinkova-Kostova AT;Fahey JW;Benedict AL;Jenkins SN;Ye L;Wehage SL;Talalay P

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将西兰花芽提取物(每日提供10 μmol硫代葡萄糖苷)喂给先前慢性暴露于紫外线辐射的SKH-1无毛小鼠(30 mJ cm-2 UVB,每周两次,持续17周)在随后的13周内抑制了皮肤肿瘤的发展;与对照组相比,在接受保护剂的动物中,肿瘤发生率、多样性和体积分别降低了25%、47%和70%。
Feeding broccoli sprout extracts providing daily doses of 10 μmol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm-2 of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.
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