Inflammatory and hematologic markers as predictors of severe outcomes in COVID-19 infection: A systematic review and meta-analysis.
Inflammatory and hematologic markers as predictors of severe outcomes in COVID-19 infection: A systematic review and meta-analysis.
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DOI：
10.1016/j.ajem.2020.12.076
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Kurniawan A
中科院分区：
文献类型：
--
作者：
Hariyanto TI;Japar KV;Kwenandar F;Damay V;Siregar JI;Lugito NPH;Tjiang MM;Kurniawan A
实验室检测通常在COVID-19患者中进行。每个实验室参数都对COVID-19的风险分层和预测结果具有潜在价值。本系统性综述和荟萃分析旨在评价这些参数在重度和非重度疾病中的差异，并提供预测重度疾病的最佳临界值。我们通过电子数据库进行了系统的文献检索。关注的变量是COVID-19严重程度结局各组的血清降钙素原、白蛋白、C反应蛋白（CRP）、D-二聚体和乳酸脱氢酶（LDH）水平。共有来自23项研究的4848例患者。我们的荟萃分析表明，严重COVID-19感染患者的降钙素原较高，（平均差异0.07; 95% CI 0.05-0.10; p < 0.00001），CRP（平均差异36.88; 95% CI 29.10-44.65; p < 0.00001），D-二聚体（平均差异0.43; 95% CI 0.31-0.56; p < 0.00001），和LDH（平均差异102.79; 95% CI 79.10-126.49; p < 0.00001），但白蛋白水平较低（平均差异为-4.58; 95% CI为-5.76至-3.39; p < 0.00001）。降钙素原、白蛋白、CRP、D-二聚体和LDH的临界值分别为0.065 ng/mL、38.85 g/L、33.55 mg/L、0.635 μ/L和263.5 U/L，均具有较高的灵敏度和特异性。这项荟萃分析表明，降钙素原、CRP、D-二聚体和LDH升高以及白蛋白降低可用于预测COVID-19的严重结局。
Laboratory testing is commonly performed in patients with COVID-19. Each of the laboratory parameters has potential value for risk stratification and prediction of COVID-19 outcomes. This systematic review and meta-analysis aimed to evaluate the difference between these parameters in severe and nonsevere disease and to provide the optimal cutoff value for predicting severe disease. We performed a systematic literature search through electronic databases. The variables of interest were serum procalcitonin, albumin, C-reactive protein (CRP), D-dimer, and lactate dehydrogenase (LDH) levels in each group of severity outcomes from COVID-19. There were a total of 4848 patients from 23 studies. Our meta-analysis suggest that patients with severe COVID-19 infections have higher procalcitonin, (mean difference 0.07; 95% CI 0.05–0.10; p < 0.00001), CRP (mean difference 36.88; 95% CI 29.10–44.65; p < 0.00001), D-Dimer (mean difference 0.43; 95% CI 0.31–0.56; p < 0.00001), and LDH (mean difference 102.79; 95% CI 79.10–126.49; p < 0.00001) but lower levels of albumin (mean difference −4.58; 95% CI −5.76 to −3.39; p < 0.00001) than those with nonsevere COVID-19 infections. The cutoff values for the parameters were 0.065 ng/mL for procalcitonin, 38.85 g/L for albumin, 33.55 mg/L for CRP, 0.635 μ/L for D-dimer, and 263.5 U/L for LDH, each with high sensitivity and specificity. This meta-analysis suggests elevated procalcitonin, CRP, D-dimer, and LDH and decreased albumin can be used for predicting severe outcomes in COVID-19.
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DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
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DOI：
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发表时间：
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影响因子：
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