Prevalence and pathogenicity of binary toxin-positive Clostridium difficile strains that do not produce toxins A and B.
Prevalence and pathogenicity of binary toxin-positive Clostridium difficile strains that do not produce toxins A and B.
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DOI：
10.1016/j.nmni.2014.10.003
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发表时间：
2015-01
影响因子：
4
通讯作者：
Barbut, F.
中科院分区：
文献类型：
--
作者：
Eckert, C.;Emirian, A.;Le Monnier, A.;Cathala, L.;De Montclos, H.;Goret, J.;Berger, P.;Petit, A.;De Chevigny, A.;Jean-Pierre, H.;Nebbad, B.;Camiade, S.;Meckenstock, R.;Lalande, V.;Marchandin, H.;Barbut, F.
艰难梭菌引起抗生素相关性腹泻和假膜性结肠炎。艰难梭菌的主要毒力因子是毒素A （TcdA）和B （TcdB）。第三种毒素，称为二元毒素（CDT），可在17%至23%的菌株中检测到，但其在人类疾病中的作用尚未明确界定。我们报告了6例独立的腹泻患者，由于毒素型XI/PCR核糖型033或033样菌株而怀疑患有艰难梭菌感染，这是一种罕见的毒素型/PCR核糖型CDT阳性，但TcdA和TcdB阴性。4例患者被临床医生认为是真正的感染，并特别给予口服甲硝唑治疗。其中一个病例是在a−B−CDT+菌株的流行研究中发现的。在这项研究中，我们筛选了法国收集的220株非产毒菌株，发现只有1株（0.5%）毒素型XI/PCR核糖型033或033样菌株。对这些菌株的描述提出了二元毒素作为一种毒力因子的作用的问题，并可能对目前很少包括二元毒素检测的实验室诊断产生影响。
Clostridium difficile causes antibiotic-associated diarrhoea and pseudomembranous colitis. The main virulence factors of C. difficile are the toxins A (TcdA) and B (TcdB). A third toxin, called binary toxin (CDT), can be detected in 17% to 23% of strains, but its role in human disease has not been clearly defined. We report six independent cases of patients with diarrhoea suspected of having C. difficile infection due to strains from toxinotype XI/PCR ribotype 033 or 033-like, an unusual toxinotype/PCR ribotype positive for CDT but negative for TcdA and TcdB. Four patients were considered truly infected by clinicians and were specifically treated with oral metronidazole. One of the cases was identified during a prevalence study of A−B−CDT+ strains. In this study, we screened a French collection of 220 nontoxigenic strains and found only one (0.5%) toxinotype XI/PCR ribotype 033 or 033-like strain. The description of such strains raises the question of the role of binary toxin as a virulence factor and could have implications for laboratory diagnostics that currently rarely include testing for binary toxin.
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影响因子：
6.4
作者：
Geric, B;Carman, RJ;Johnson, S
通讯作者：
Johnson, S
影响因子：
11.8
作者：
Bacci, Sabrina;Molbak, Kare;Olsen, Katharine E. P.
通讯作者：
Olsen, Katharine E. P.
影响因子：
158.5
作者：
McDonald, LC;Killgore, GE;Gerding, DN
通讯作者：
Gerding, DN
DOI：
10.1016/j.diagmicrobio.2010.02.019
发表时间：
2010-07-01
影响因子：
2.9
作者：
Goldenberg, Simon D.;Dieringer, Thomas;French, Gary L.
通讯作者：
French, Gary L.
影响因子：
3
作者：
Eckert, Catherine;Burghoffer, Beatrice;Barbut, Frederic
通讯作者：
Barbut, Frederic