The importance of immune responses in a model of hepatitis B virus
The importance of immune responses in a model of hepatitis B virus
复制标题
乙型肝炎病毒模型中免疫反应的重要性
DOI：
10.1007/s11071-011-0022-6
复制
发表时间：
2012
影响因子：
5.6
通讯作者：
崔景安
中科院分区：
文献类型：
--
作者：
惠静;庞建华;崔景安
In this paper, the dynamical behavior of a hepatitis B virus model with CTL immune responses is studied. Analyzing the model, we show that the virus-free equilibrium is globally asymptotically stable if the basic reproductive ratio of virus is less than one and the endemic equilibrium is locally asymptotically stable if the basic reproductive ratio is greater than one. When the basic reproductive ratio is greater than one, the system is uniformly persistent, which means the virus is endemic. Mathematical analysis and numerical simulations show that the CTL immune responses play a significant and decisive role in eradication of disease. The study and information derived from this model may have an important impact on treatment protocols of hepatitis B virus in the future.
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DOI：
10.1090/s0002-9939-1986-0822433-4
发表时间：
1986-03
期刊：
--
影响因子：
--
作者：
G. Butler;H. I. FREEDMAN1;Paul WALTMAN2;H. I. Freedman
通讯作者：
G. Butler;H. I. FREEDMAN1;Paul WALTMAN2;H. I. Freedman
影响因子：
5.6
作者：
Xia Wang;Youde Tao;Xinyu Song
通讯作者：
Xia Wang;Youde Tao;Xinyu Song
DOI：
10.1073/pnas.93.9.4398
发表时间：
1996-04-30
影响因子：
11.1
作者：
Nowak, MA;Bonhoeffer, S;McDade, H
通讯作者：
McDade, H
影响因子：
1.4
作者：
Xiaohong Tian;R. Xu
通讯作者：
Xiaohong Tian;R. Xu
影响因子：
6.4
作者：
MCMAHON, BJ;ALWARD, WLM;MAYNARD, JE
通讯作者：
MAYNARD, JE