Preventive effect of permethrin-impregnated long-lasting insecticidal nets on the blood feeding of three major pyrethroid-resistant malaria vectors in western Kenya.
Preventive effect of permethrin-impregnated long-lasting insecticidal nets on the blood feeding of three major pyrethroid-resistant malaria vectors in western Kenya.
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DOI：
10.1186/1756-3305-7-383
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发表时间：
2014-08-20
影响因子：
3.2
通讯作者：
Minakawa N
中科院分区：
文献类型：
--
作者：
Kawada H;Ohashi K;Dida GO;Sonye G;Njenga SM;Mwandawiro C;Minakawa N
自从世界卫生组织(世卫组织)将使用长效杀虫蚊帐作为有效预防和控制疟疾的主要战略以来，拟除虫菊酯一直是长效杀虫蚊帐使用的唯一一类杀虫剂。然而，驱虫蚊帐和驱虫蚊帐在非洲国家的巨大成功受到了媒介蚊虫对拟除虫菊酯耐药性的迅速发展的威胁。ITN和LLIN仍然被用作有效的自我保护措施，但在媒介蚊子对拟除虫菊酯产生抗药性的地区，关于ITN和LLIN的有效性的研究很少。为了解室内蚊虫的行为模式，对冈比亚按蚊Anopheles gbiae S.S.，An.Arabiens和An.Funestus S.S.在 下午4：00至 上午8：00之间，每隔2小时使用配备收集瓶旋转器的疾病控制和预防中心微型捕光器进行检查。被诱捕的雌性蚊子被鉴定并归类为未喂食、吸血和怀孕。取喂食雌蚊的腹部内容物进行DNA提取，以确定血源。人类有很大比例的血液是以AN为食的。Arabiens和An.Funestus S.S.(但不是。冈比亚亚种(Gbiae S.S.)发生在人们活跃在LLIN之外的时间。然而，在人们处于LLIN之下的几个小时内，这些LLIN提供了保护效果，这表明人类的血液喂食率降低了。LLIN在睡前提供了对抗拟除虫菊酯疟疾媒介种群的有效保护。然而，在人们在蚊帐外活动的时间里，对LLIN的保护不足。在不久的将来，非洲国家将需要深入解决这种对LLIN的限制问题。
Since the World Health Organization (WHO) adopted the use of long-lasting insecticidal nets (LLINs) as a principal strategy for effective malaria prevention and control, pyrethroids have been the only class of insecticides used for LLINs. The dramatic success of insecticide-treated nets (ITNs) and LLINs in African countries, however, has been threatened by the rapid development of pyrethroid resistance in vector mosquitoes. ITNs and LLINs are still used as effective self-protection measures, but there have been few studies on the effectiveness of ITNs and LLINs in areas where vector mosquitoes are pyrethroid-resistant. To investigate the behavioral pattern of mosquitoes in the houses where LLINs were used, indoor mosquito trappings of Anopheles gambiae s.s., An. arabiensis, and An. funestus s.s. were performed with Centers for Disease Control and Prevention (CDC) miniature light trap equipped with a collection bottle rotator at 2-hour intervals between 4:00 pm and 8:00 am. The trapped female mosquitoes were identified and classified as unfed, blood fed, and gravid. The abdominal contents of fed female mosquitoes were used for DNA extractions to identify the blood source. A large proportion of human blood feeding of An. arabiensis and An. funestus s.s. (but not An. gambiae s.s.) took place during the time people were active outside LLINs. However, during the hours when people were beneath LLINs, these provided protective efficacy as indicated by reduced human blood feeding rates. LLINs provided effective protection against pyrethroid-resistant malaria vector populations during bedtime hours. However, protection of LLINs was insufficient during the hours when people were active outside of the bed nets. Such limitation of LLINs will need to be intensively addressed in African countries in the near future.
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影响因子：
3
作者：
Bhatt, Rajendra M.;Sharma, Shri N.;Kamaraju, Raghavendra
通讯作者：
Kamaraju, Raghavendra
DOI：
10.4269/ajtmh.2002.66.804
发表时间：
2002-06-01
影响因子：
3.3
作者：
Koekemoer, LL;Kamau, L;Coetzee, M
通讯作者：
Coetzee, M
影响因子：
2.1
作者：
Kawada, H;Takagi, M
通讯作者：
Takagi, M
DOI：
10.4269/ajtmh.2005.73.336
发表时间：
2005-08-01
影响因子：
3.3
作者：
Kent, RJ;Norris, DE
通讯作者：
Norris, DE
影响因子：
2.2
作者：
Kawada, Hitoshi;Dida, Gabriel O.;Takagi, Masahiro
通讯作者：
Takagi, Masahiro