Dopamine Signaling in Substantia Nigra and Its Impact on Locomotor Function-Not a New Concept, but Neglected Reality.
Dopamine Signaling in Substantia Nigra and Its Impact on Locomotor Function-Not a New Concept, but Neglected Reality.
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DOI：
10.3390/ijms25021131
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发表时间：
2024-01-17
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
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多巴胺（DA）信号传导的机制影响和对运动功能的影响几乎总是从纹状体黑质纹状体神经元末梢的变化来解释。这是研究人类帕金森病（PD）和衰老以及PD和衰老相关帕金森病动物模型的标准做法。然而，尽管数十项研究表明纹状体DA信号的变化与运动表型之间的关系不明确，但对纹状体的持续关注仍在继续。尽管近50年前首次报道了黑质（SN）中的DA释放，但很少考虑与运动功能相关的黑质DA信号变化的评估。尽管在纹状体中，DA信号已经在黑质纹状体通路的所有五个神经传递步骤（生物合成和转换、储存、释放、再摄取和突触后结合）中得到了很好的表征，但在SN中，除细胞计数外，这种询问的深度很少。然而，有足够的证据表明，这些DA神经传递的步骤是由纹状体自主操作和调节的，并且存在于人类PD和衰老及相关动物模型中。为了完善我们对黑质纹状体DA信号如何影响运动功能的理解，对黑质DA信号的研究是过去的事情。这篇简短的综述强调了在DA神经传递的每一步中，神经DA信号的变化是独立于纹状体的，而SN的变化可以单独影响运动功能。因此，为了充分表征黑质纹状体DA信号如何影响运动活动，研究SN中的DA信号是必不可少的。
The mechanistic influences of dopamine (DA) signaling and impact on motor function are nearly always interpreted from changes in nigrostriatal neuron terminals in striatum. This is a standard practice in studies of human Parkinson’s disease (PD) and aging and related animal models of PD and aging-related parkinsonism. However, despite dozens of studies indicating an ambiguous relationship between changes in striatal DA signaling and motor phenotype, this perseverating focus on striatum continues. Although DA release in substantia nigra (SN) was first reported almost 50 years ago, assessment of nigral DA signaling changes in relation to motor function is rarely considered. Whereas DA signaling has been well-characterized in striatum at all five steps of neurotransmission (biosynthesis and turnover, storage, release, reuptake, and post-synaptic binding) in the nigrostriatal pathway, the depth of such interrogations in the SN, outside of cell counts, is sparse. However, there is sufficient evidence that these steps in DA neurotransmission in the SN are operational and regulated autonomously from striatum and are present in human PD and aging and related animal models. To complete our understanding of how nigrostriatal DA signaling affects motor function, it is past time to include interrogation of nigral DA signaling. This brief review highlights evidence that changes in nigral DA signaling at each step in DA neurotransmission are autonomous from those in striatum and changes in the SN alone can influence locomotor function. Accordingly, for full characterization of how nigrostriatal DA signaling affects locomotor activity, interrogation of DA signaling in SN is essential.
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DOI：
10.1176/appi.neuropsych.19.1.65
发表时间：
2007-02-01
影响因子：
2.9
作者：
Ankenman, Ralph;Salvatore, Michael F.
通讯作者：
Salvatore, Michael F.
DOI：
10.1093/brain/awad388
发表时间：
2024-02-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.1
作者：
Chotibut T;Davis RW;Arnold JC;Frenchek Z;Gurwara S;Bondada V;Geddes JW;Salvatore MF
通讯作者：
Salvatore MF
影响因子：
2.9
作者：
Bergquist, F;Shahabi, HN;Nissbrandt, H
通讯作者：
Nissbrandt, H
影响因子：
9.9
作者：
Beauchamp, Leah C.;Dore, Vincent;Rowe, Christopher
通讯作者：
Rowe, Christopher