Orbitofrontal cortex is required for optimal waiting based on decision confidence.
Orbitofrontal cortex is required for optimal waiting based on decision confidence.
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DOI：
10.1016/j.neuron.2014.08.039
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发表时间：
2014-10-01
期刊：
影响因子：
16.2
通讯作者：
Kepecs, Adam
中科院分区：
文献类型：
--
作者：
Lak, Armin;Costa, Gil M.;Romberg, Erin;Koulakov, Alexei A.;Mainen, Zachary F.;Kepecs, Adam
信心判断是元认知的一个核心例子，元认知是关于一个人自己的认知过程的知识。根据这种元认知观点，信心报告是由基于信念内部表征质量的二阶监控过程生成的。尽管最近在人类和其他动物中发现了决策信心的神经相关性，但尚不清楚是否存在对于信心监控特别重要的大脑区域。为了解决这个问题，我们设计了一个决策后时间投注任务，其中老鼠通过愿意等待奖励的时间来表达选择信心。我们发现，眶额皮层失活会扰乱基于等待的信心报告，但不会影响决策的准确性。此外，我们表明规范模型可以根据决策置信度的计算定量地解释等待时间。这些结果为元认知报告、置信度判断建立了解剖学轨迹，与感知决策所需的过程不同。
Confidence judgments are a central example of metacognition—knowledge about one’s own cognitive processes. According to this metacognitive view, confidence reports are generated by a second-order monitoring process based on the quality of internal representations about beliefs. Although neural correlates of decision confidence have been recently identified in humans and other animals, it is not well understood whether there are brain areas specifically important for confidence monitoring. To address this issue, we designed a postdecision temporal wagering task in which rats expressed choice confidence by the amount of time they were willing to wait for reward. We found that orbitofrontal cortex inactivation disrupts waiting-based confidence reports without affecting decision accuracy. Furthermore, we show that a normative model can quantitatively account for waiting times based on the computation of decision confidence. These results establish an anatomical locus for a metacognitive report, confidence judgment, distinct from the processes required for perceptual decisions.
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DOI：
10.1073/pnas.0607716103
发表时间：
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影响因子：
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