Ancient DNA and deep population structure in sub-Saharan African foragers.
Ancient DNA and deep population structure in sub-Saharan African foragers.
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DOI：
10.1038/s41586-022-04430-9
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
Prendergast ME
中科院分区：
文献类型：
--
作者：
Lipson M;Sawchuk EA;Thompson JC;Oppenheimer J;Tryon CA;Ranhorn KL;de Luna KM;Sirak KA;Olalde I;Ambrose SH;Arthur JW;Arthur KJW;Ayodo G;Bertacchi A;Cerezo-Román JI;Culleton BJ;Curtis MC;Davis J;Gidna AO;Hanson A;Kaliba P;Katongo M;Kwekason A;Laird MF;Lewis J;Mabulla AZP;Mapemba F;Morris A;Mudenda G;Mwafulirwa R;Mwangomba D;Ndiema E;Ogola C;Schilt F;Willoughby PR;Wright DK;Zipkin A;Pinhasi R;Kennett DJ;Manthi FK;Rohland N;Patterson N;Reich D;Prendergast ME
多种遗传和考古证据表明，撒哈拉以南非洲的晚更新世末期和全新世早期发生了重大的人口变化。关于这一时期的推论很难做出，因为过去 5000 年的人口变化掩盖了更古老的人口结构。在这里，我们提供了过去大约 18,000 年中来自非洲东部和中南部的 6 个个体的全基因组古代 DNA 数据（使撒哈拉以南非洲古代 DNA 的时间深度加倍），提高了 15 个先前发表的古代个体的数据质量，并将这些数据与其他 13 个已发表的古代个体的数据一起进行分析。我们研究区域中个体的祖先可以被建模为三个高度不同的来源种群的地理结构混合物，可能反映了大约8万至2万年前更新世的相互作用，包括截然不同的东部和南部非洲血统，加上以前未被认识到的无处不在的祖先分布，这种分布在今天的非洲中部雨林狩猎采集者中比例最高。一旦建立，这种结构就保持高度稳定，远程基因流有限。这些结果提供了一系列新的遗传证据，支持考古分析中出现的但仍存在争议的假设，表明更新世末期的区域化不断增强。对过去大约 18,000 年来自非洲东部和中南部的 6 个个体以及之前发表的 28 个古代个体的 DNA 分析提供了遗传证据，支持更新世末期区域化加剧的假设。
Multiple lines of genetic and archaeological evidence suggest that there were major demographic changes in the terminal Late Pleistocene epoch and early Holocene epoch of sub-Saharan Africa. Inferences about this period are challenging to make because demographic shifts in the past 5,000 years have obscured the structures of more ancient populations. Here we present genome-wide ancient DNA data for six individuals from eastern and south-central Africa spanning the past approximately 18,000 years (doubling the time depth of sub-Saharan African ancient DNA), increase the data quality for 15 previously published ancient individuals and analyse these alongside data from 13 other published ancient individuals. The ancestry of the individuals in our study area can be modelled as a geographically structured mixture of three highly divergent source populations, probably reflecting Pleistocene interactions around 80–20 thousand years ago, including deeply diverged eastern and southern African lineages, plus a previously unappreciated ubiquitous distribution of ancestry that occurs in highest proportion today in central African rainforest hunter-gatherers. Once established, this structure remained highly stable, with limited long-range gene flow. These results provide a new line of genetic evidence in support of hypotheses that have emerged from archaeological analyses but remain contested, suggesting increasing regionalization at the end of the Pleistocene epoch. DNA analysis of 6 individuals from eastern and south-central Africa spanning the past approximately 18,000 years, and of 28 previously published ancient individuals, provides genetic evidence supporting hypotheses of increasing regionalization at the end of the Pleistocene.
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影响因子：
16.6
作者：
Kennett DJ;Plog S;George RJ;Culleton BJ;Watson AS;Skoglund P;Rohland N;Mallick S;Stewardson K;Kistler L;LeBlanc SA;Whiteley PM;Reich D;Perry GH
通讯作者：
Perry GH
影响因子：
64.8
作者：
Fu Q;Posth C;Hajdinjak M;Petr M;Mallick S;Fernandes D;Furtwängler A;Haak W;Meyer M;Mittnik A;Nickel B;Peltzer A;Rohland N;Slon V;Talamo S;Lazaridis I;Lipson M;Mathieson I;Schiffels S;Skoglund P;Derevianko AP;Drozdov N;Slavinsky V;Tsybankov A;Cremonesi RG;Mallegni F;Gély B;Vacca E;Morales MR;Straus LG;Neugebauer-Maresch C;Teschler-Nicola M;Constantin S;Moldovan OT;Benazzi S;Peresani M;Coppola D;Lari M;Ricci S;Ronchitelli A;Valentin F;Thevenet C;Wehrberger K;Grigorescu D;Rougier H;Crevecoeur I;Flas D;Semal P;Mannino MA;Cupillard C;Bocherens H;Conard NJ;Harvati K;Moiseyev V;Drucker DG;Svoboda J;Richards MP;Caramelli D;Pinhasi R;Kelso J;Patterson N;Krause J;Pääbo S;Reich D
通讯作者：
Reich D
影响因子：
56.9
作者：
Brooks, Alison S.;Yellen, John E.;Clark, Jennifer B.
通讯作者：
Clark, Jennifer B.
影响因子：
3
作者：
Korneliussen TS;Albrechtsen A;Nielsen R
通讯作者：
Nielsen R
影响因子：
2.7
作者：
Korlevic, Petra;Gerber, Tobias;Meyer, Matthias
通讯作者：
Meyer, Matthias