Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1.
Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1.
复制标题
DOI：
10.3389/fimmu.2021.688254
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Bachstetter AD
中科院分区：
文献类型：
--
作者：
Bodnar CN;Watson JB;Higgins EK;Quan N;Bachstetter AD
有几个屏障将中枢神经系统（CNS）与身体的其他部分分开。这些屏障对于调节液体、离子、分子和免疫细胞进出脑实质的运动至关重要。每个CNS屏障都是独特的和高度动态的。内皮细胞、上皮细胞、周细胞、星形胶质细胞和其他细胞成分各自具有维持大脑健康所必需的复杂功能。沿着损伤神经元，创伤性脑损伤（TBI）也直接损害CNS屏障形成细胞。屏障的破坏首先发生在细胞的物理损伤，称为原发性损伤。随后，在继发性损伤级联过程中，屏障处发生进一步的分子和生化变化。这些变化的重点是重建和重塑，以及免疫细胞和废物进出大脑的运动。继发性损伤级联进一步损害中枢神经系统屏障。炎症是中枢神经系统屏障健康重塑的核心。然而，炎症作为次要病理学，也在TBI后屏障功能的慢性破坏中发挥作用。本文就脑的不同屏障进行综述，包括（1）血脑屏障，（2）血脑脊液屏障，（3）脑膜屏障，（4）血视网膜屏障，（5）脑病变边界。然后，我们详细介绍了这些障碍的变化，由于原发性和继发性损伤后TBI，并指出开放的领域，为未来的研究和发现。最后，我们描述了独特的功能，促炎细胞因子白细胞介素-1作为一个中央演员在炎症调节中枢神经系统屏障功能和功能障碍后，创伤性脑损伤。
Several barriers separate the central nervous system (CNS) from the rest of the body. These barriers are essential for regulating the movement of fluid, ions, molecules, and immune cells into and out of the brain parenchyma. Each CNS barrier is unique and highly dynamic. Endothelial cells, epithelial cells, pericytes, astrocytes, and other cellular constituents each have intricate functions that are essential to sustain the brain’s health. Along with damaging neurons, a traumatic brain injury (TBI) also directly insults the CNS barrier-forming cells. Disruption to the barriers first occurs by physical damage to the cells, called the primary injury. Subsequently, during the secondary injury cascade, a further array of molecular and biochemical changes occurs at the barriers. These changes are focused on rebuilding and remodeling, as well as movement of immune cells and waste into and out of the brain. Secondary injury cascades further damage the CNS barriers. Inflammation is central to healthy remodeling of CNS barriers. However, inflammation, as a secondary pathology, also plays a role in the chronic disruption of the barriers’ functions after TBI. The goal of this paper is to review the different barriers of the brain, including (1) the blood-brain barrier, (2) the blood-cerebrospinal fluid barrier, (3) the meningeal barrier, (4) the blood-retina barrier, and (5) the brain-lesion border. We then detail the changes at these barriers due to both primary and secondary injury following TBI and indicate areas open for future research and discoveries. Finally, we describe the unique function of the pro-inflammatory cytokine interleukin-1 as a central actor in the inflammatory regulation of CNS barrier function and dysfunction after a TBI.
登录
查看更多内容
影响因子：
5.3
作者：
Burda JE;Bernstein AM;Sofroniew MV
通讯作者：
Sofroniew MV
影响因子：
2.8
作者：
CASTEJON, OJ
通讯作者：
CASTEJON, OJ
影响因子：
1.9
作者：
Balabanov, R;Goldman, H;Dore-Duffy, P
通讯作者：
Dore-Duffy, P
DOI：
10.1073/pnas.0808698106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Argaw, Azeb Tadesse;Gurfein, Blake T.;John, Gareth R.
通讯作者：
John, Gareth R.
影响因子：
5.3
作者：
Ching, San;Zhang, Hao;Quan, Ning
通讯作者：
Quan, Ning