Serotonin neuron abnormalities in the BTBR mouse model of autism.
Serotonin neuron abnormalities in the BTBR mouse model of autism.
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DOI：
10.1002/aur.1665
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Commons KG
中科院分区：
文献类型：
--
作者：
Guo YP;Commons KG
我研究的近交系小鼠品系BTBR T+Itpr3tf/J(BTBR)是特发性自闭症的模型，因为它们比其他品系更少群居，更耐变化。BTBR小鼠的前脑5-羟色胺受体和对5-羟色胺药物的反应发生了变化，但5-羟色胺神经元本身是否异常仍是个未知数。在本研究中，我们发现与C57BL/6J(C57)小鼠相比，BTBR小鼠海马区5-羟色胺组织含量和5-羟色胺轴突密度降低。伴随而来的可能是5-羟色胺神经元的代偿性变化，这些神经元在已知为海马体提供神经支配的区域：尾侧背中缝(B6)和中缝中缝最明显。这些变化包括5-羟色胺神经元数量的增加和Fos表达的过度激活。中缝背侧2/3区5-羟色胺神经元和前额叶皮质5-羟色胺含量受到的影响较小。因此，5-羟色胺神经元在BTBR小鼠中表现出区域依赖性的异常，这可能有助于它们的行为特征的改变。
The inbred mouse strain BTBR T+ Itpr3tf/J (BTBR) i studied as a model of idiopathic autism because they are less social and more resistant to change than other strains. Forebrain serotonin receptors and the response to serotonin drugs are altered in BTBR mice, yet it remains unknown if serotonin neurons themselves are abnormal. In this study, we found that serotonin tissue content and the density of serotonin axons is reduced in the hippocampus of BTBR mice in comparison to C57BL/6J (C57) mice. This was accompanied by possible compensatory changes in serotonin neurons that were most pronounced in regions known to provide innervation to the hippocampus: the caudal dorsal raphe (B6) and the median raphe. These changes included increased numbers of serotonin neurons and hyperactivation of Fos expression. Metrics of serotonin neurons in the rostral 2/3 of the dorsal raphe and serotonin content of the prefrontal cortex were less impacted. Thus, serotonin neurons exhibit region-dependent abnormalities in the BTBR mouse that may contribute to their altered behavioral profile.
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