Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study.
Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study.
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HAART 早期和晚期癌症发病率的变化模式：瑞士 HIV 队列研究。
DOI：
10.1038/sj.bjc.6605756
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发表时间：
2010-07-27
影响因子：
8.8
通讯作者：
Keiser, O.
中科院分区：
文献类型：
--
作者：
Franceschi, S.;Lise, M.;Clifford, G. M.;Rickenbach, M.;Levi, F.;Maspoli, M.;Bouchardy, C.;Dehler, S.;Jundt, G.;Ess, S.;Bordoni, A.;Konzelmann, I.;Frick, H.;Dal Maso, L.;Elzi, L.;Furrer, H.;Calmy, A.;Cavassini, M.;Ledergerber, B.;Keiser, O.
1996年，高效抗逆转录病毒疗法（HAART）的出现导致卡波西肉瘤（KS）和非霍奇金淋巴瘤（NHL）的发病率下降，但在艾滋病毒或艾滋病（PWHA）患者中，其他癌症的发病率没有下降。这也导致他们的预期寿命显著增加。我们在瑞士HIV队列研究和9个瑞士州癌症登记处之间进行了一项记录关联研究。总共有9429例PWHA在HAART前、早期和晚期分别提供了20615、17690和15410人年。计算不同时期PWHA与一般人群的标准化发病率比，以及年龄标准化和年龄特异性发病率。KS和NHL的发病率在HAART前期和早期之间下降了几倍，并且从早期到晚期HAART期间也有所下降。肛门癌、肝癌、非黑色素瘤性皮肤癌和霍奇金淋巴瘤的发病率在HAART早期较前增加，但在HAART晚期没有增加。所有非艾滋病定义的癌症（NADC）的发病率在所有时期都相似，大约是普通人群的两倍。在引入HAART后，选定NADC的发病率增加主要是由于PWHA的老化。
The advent of highly active antiretroviral therapy (HAART) in 1996 led to a decrease in the incidence of Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL), but not of other cancers, among people with HIV or AIDS (PWHA). It also led to marked increases in their life expectancy. We conducted a record-linkage study between the Swiss HIV Cohort Study and nine Swiss cantonal cancer registries. In total, 9429 PWHA provided 20 615, 17 690, and 15 410 person-years in the pre-, early-, and late-HAART periods, respectively. Standardised incidence ratios in PWHA vs the general population, as well as age-standardised, and age-specific incidence rates were computed for different periods. Incidence of KS and NHL decreased by several fold between the pre- and early-HAART periods, and additionally declined from the early- to the late-HAART period. Incidence of cancers of the anus, liver, non-melanomatous skin, and Hodgkin's lymphoma increased in the early- compared with the pre-HAART period, but not during the late-HAART period. The incidence of all non-AIDS-defining cancers (NADCs) combined was similar in all periods, and approximately double that in the general population. Increases in the incidence of selected NADCs after the introduction of HAART were largely accounted for by the ageing of PWHA.
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影响因子：
20.3
作者：
Biggar, Robert J.;Jaffe, Elaine S.;Engels, Eric A.
通讯作者：
Engels, Eric A.
影响因子：
3.8
作者：
Bower, M;Powles, T;Gazzard, B
通讯作者：
Gazzard, B
影响因子：
8.8
作者：
Dal Maso, L.;Polesel, J.;Franceschi, S.
通讯作者：
Franceschi, S.
影响因子：
11.8
作者：
Kirk, Gregory D.;Merlo, Christian;Engels, Eric A.
通讯作者：
Engels, Eric A.
影响因子：
8.8
作者：
Franceschi, S.;Dal Maso, L.;Rickenbach, M.;Polesel, J.;Hirschel, B.;Cavassini, M.;Bordoni, A.;Elzi, L.;Ess, S.;Jundt, G.;Mueller, N.;Clifford, G. M.
通讯作者：
Clifford, G. M.