Magnetic resonance spectroscopic imaging of downfield proton resonances in the human brain at 3 T.
Magnetic resonance spectroscopic imaging of downfield proton resonances in the human brain at 3 T.
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DOI：
10.1002/mrm.29142
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发表时间：
2022-04
影响因子：
3.3
通讯作者：
Barker PB
中科院分区：
文献类型：
--
作者：
Považan M;Schär M;Gillen J;Barker PB
开发一种能够绘制人脑低场质子共振图的 MRSI 技术。开发了光谱空间激励和频率选择性重聚焦方案，与二维相位编码相结合，用于在不对水磁化强度进行任何扰动的情况下绘制低场共振图。还研究了使用光谱空间重聚焦的替代方案，以同时检测下场和上场共振。该方法在 5 名正常人类志愿者中进行了测试。标称空间分辨率为 1.5 cm3 的前场代谢图在 3T、扫描时间为 12 分钟内记录。 9 个不同低场峰值的 Cramer-Rao 下限 (CRLB) 为单个室上切片的 20% 或更低。前场光谱轮廓与之前使用单体素定位方法记录的文献中的光谱轮廓相似。同样的方法也用于前场 MRSI 以及同时上场和下场采集。所开发的 MRSI 脉冲序列被证明是一种在 3T 下快速绘制人脑低场共振的有效方法，通过松弛增强效应最大限度地提高灵敏度。由于 MRSI 方法在数据收集方面非常高效，并且可以在短 TE 下轻松实施，因此可以实现比之前的单体素前场 MRS 研究报告更高的空间分辨率。通过这种方法，首次使用 3T 的 MRSI 将 9 个低场共振映射到单个切片中。
To develop an MRSI technique capable of mapping downfield proton resonances in the human brain. A spectral-spatial excitation and frequency selective refocusing scheme, in combination with 2D phase-encoding, was developed for mapping of downfield resonances without any perturbation of the water magnetization. An alternative scheme using spectral-spatial refocusing was also investigated for simultaneous detection of both downfield and upfield resonances. The method was tested in 5 normal human volunteers. Downfield metabolite maps with a nominal spatial resolution of 1.5 cm3 were recorded at 3T in a scan time of 12 minutes. Cramer-Rao Lower Bounds (CRLBs) for 9 different downfield peaks were 20% or less over a single supraventricular slice. Downfield spectral profiles were similar to those in the literature recorded previously using single voxel localization methods. The same approach was also used for upfield MRSI, and simultaneous upfield and downfield acquisitions. The MRSI pulse-sequence developed was shown to be an efficient way of rapidly mapping downfield resonances in the human brain at 3T, maximizing sensitivity through the relaxation enhancement effect. Since the MRSI approach is efficient in terms of data collection and can be readily implemented at short TE, somewhat higher spatial resolution can be achieved than has been reported in previous single-voxel downfield MRS studies. With this approach, 9 downfield resonances could be mapped in a single slice for the first time using MRSI at 3T.
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影响因子：
3.3
作者：
Schaer, Michael;Vonken, Evert-Jan;Stuber, Matthias
通讯作者：
Stuber, Matthias
影响因子：
2.2
作者：
HORE, PJ
通讯作者：
HORE, PJ
影响因子：
2.9
作者：
Maudsley AA;Andronesi OC;Barker PB;Bizzi A;Bogner W;Henning A;Nelson SJ;Posse S;Shungu DC;Soher BJ
通讯作者：
Soher BJ
影响因子：
3.3
作者：
Borbath, Tamas;Murali-Manohar, Saipavitra;Henning, Anke
通讯作者：
Henning, Anke
影响因子：
3.3
作者：
MEYER, CH;PAULY, JM;NISHIMURA, DG
通讯作者：
NISHIMURA, DG