Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations.

Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations.
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DOI:
10.1002/nbm.4309
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发表时间:
2021-05
期刊:
影响因子:
2.9
通讯作者:
Soher BJ
Soher BJ
中科院分区:
医学3区
文献类型:
--
作者:
Maudsley AA;Andronesi OC;Barker PB;Bizzi A;Bogner W;Henning A;Nelson SJ;Posse S;Shungu DC;Soher BJ

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磁共振光谱成像(MRSI)为监测与疾病或损伤相关的代谢变化提供了相当大的希望;然而,到目前为止,这些方法还没有对临床护理产生重大影响,它们的使用仍然主要局限于研究界和有限数量的临床站点。二十年来,目前在临床MRI仪器上实施的MRSI方法基本保持不变,只是在序列实施上进行了渐进式改进。在此期间,已经发生了许多技术发展,这些技术已经极大地提高了MRSI测量的质量,并有望将先进的MRSI研究提升到使该技术成为真正的成像方式的程度,而使传统的单个光谱审查成为次要要求。此外,越来越多的生物医学磁共振光谱研究表明,在临床领域,先进的磁共振成像方法可以为临床护理提供有价值的信息。鉴于这种快速变化的技术环境和对核磁共振成像研究在生物医学研究中的价值的日益理解,本文提出了该领域一组专家的共识,他们回顾了人类大脑临床质子核磁共振成像研究的最新进展,为供应商提供的核磁共振成像实施的进一步发展提出了最低标准,并确定了需要进一步技术发展的领域。
Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and their use remains largely confined to the research community and a limited number of clinical sites. The MRSI methods currently implemented on clinical MRI instruments have remained essentially unchanged for two decades, with only incremental improvements in sequence implementation. During this time, a number of technological developments have taken place that have already greatly benefited the quality of MRSI measurements within the research community and which promise to bring advanced MRSI studies to the point where the technique becomes a true imaging modality, while making the traditional review of individual spectra a secondary requirement. Furthermore, the increasing use of biomedical MR spectroscopy studies has indicated clinical areas where advanced MRSI methods can provide valuable information for clinical care. In light of this rapidly changing technological environment and growing understanding of the value of MRSI studies for biomedical studies, this article presents a consensus from a group of experts in the field that reviews the state-of-the-art for clinical proton MRSI studies of the human brain, recommends minimal standards for further development of vendor-provided MRSI implementations, and identifies areas which need further technical development.
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