A Study to Draw a Normative Database of Laryngopharynx pH Profile in Chinese.
A Study to Draw a Normative Database of Laryngopharynx pH Profile in Chinese.
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DOI：
10.5056/jnm13138
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发表时间：
2014-07-31
影响因子：
3.4
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Feng G;Wang J;Zhang L;Liu Y
建立中国人咽喉部pH值的标准数据库。于2008年5月至2009年12月从www.Ganji.com“和人民医院招募正常志愿者。根据制造商的说明书，在pH 7和pH 4缓冲溶液中校准Restech pH探针。每名志愿者被要求佩戴该设备24小时，并被鼓励参与正常的日常活动。健康志愿者包括20名男性和9名女性，中位年龄为23岁（四分位距，21至32岁）。口咽pH导管在pH < 4、pH < 4.5、pH < 5.0和pH < 5.5时的总时间百分比的第95次重复计数分别为0.06%、1.01%、7.23%和27.34%。pH < 4、pH < 4.5、pH < 5.0和pH < 5.5时，24小时内反流事件数量的第95百分位数分别为2.0、18.0、107.5和284.5。这是第一项系统评估新型pH探头在健康无症状中国志愿者中检测到的反流程度并报告中国人群正常值的研究。使用口咽pH导管监测咽喉反流表明，在健康中国人中，如果pH小于4.5的时间百分比不超过1%，则反流应被视为正常。
To draw a normative database of laryngopharynx pH profile in Chinese subjects. Normal volunteers were recruited from “www.Ganji.com” and People’s hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's instructions. Each volunteer was asked to wear the device for a 24-hour period and was encouraged to participate in normal daily activities. The healthy volunteers consisted of 20 males and 9 females with a median age of 23 years (interquartile range, 21 to 32 years). The 95th percentiles for % total times at pH < 4, pH < 4.5, pH < 5.0 and pH < 5.5 for the oropharynx pH catheter were 0.06%, 1.01%, 7.23% and 27.34%, respectively. The 95th percentile for number of reflux events within the 24-hour period at pH < 4, pH < 4.5, pH < 5.0 and pH < 5.5 were 2.0, 18.0, 107.5 and 284.5, respectively. This is the first study to systematically assess the degree of reflux detected by the new pH probe in healthy asymptomatic Chinese volunteers and to report normative values in Chinese people. Using an oropharyngeal pH catheter to monitor laryngopharyngeal reflux indicated that in healthy Chinese, reflux should be considered normal if the percent time at pH less than 4.5 is no more than 1%.
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