25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma.
25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma.
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DOI：
10.1136/bjo.2009.167940
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发表时间：
2010-05
期刊：
影响因子：
--
通讯作者：
Nussenblatt RB
中科院分区：
文献类型：
--
作者：
Yeh S;Weichel ED;Faia LJ;Albini TA;Wroblewski KK;Stetler-Stevenson M;Ruiz P;Sen HN;Chan CC;Nussenblatt RB
诊断性睫状体平坦部玻璃体切除术是诊断眼内淋巴瘤（IOL）的有用技术;然而，经结膜无缝合玻璃体切除术（TSV）在该适应症中的作用尚未得到充分探讨。本研究的目的是回顾我们使用25号TSV诊断IOL的经验。对来自两个三级转诊中心的接受25号TSV诊断IOL（原发性、继发性或复发性）的患者进行了审查。对人口统计学数据和基础疾病进行了审查。评估术前和术后视力（VA）和眼科检查数据。对细胞病理学、流式细胞术、细胞因子和基因重排研究进行了评估。12名患者接受了25号诊断性TSV，中位随访时间为37周。3/12例患者（25%，95% CI 8.9 - 53.2%）和8例患者（67%，95% CI 39.1 - 86.1%）使用连续性诊断试验根据细胞学诊断为B细胞或T细胞IOL。11只眼（92%）视力稳定或改善。平均VA从20/95改善至20/66（p=0.055，配对t检验）。25-Gauge TSV是一种安全有效的获取玻璃体标本的方法。眼科病理专家会诊、流式细胞术、细胞因子检测和基因重排研究对诊断至关重要。
Diagnostic pars plana vitrectomy is a useful technique in the diagnosis of intraocular lymphoma (IOL); however, the role of transconjunctival sutureless vitrectomy (TSV) has not been fully explored for this indication. The purpose of this study was to review our experience with 25-gauge TSV for the diagnosis of IOL. Patients who underwent 25-gauge TSV for the diagnosis of IOL (primary, secondary or recurrent) from two tertiary referral centres were reviewed. Demographic data and underlying medical conditions were reviewed. Preoperative and postoperative visual acuities (VA) and ophthalmic examination data were assessed. Cytopathology, flow cytometry, cytokine and gene rearrangement studies were assessed. Twelve patients underwent 25-gauge diagnostic TSV with a median follow-up time of 37 weeks. B-cell or T-cell IOL was diagnosed based on cytology in 3/12 patients (25%, 95% CI 8.9 to 53.2%) and in eight patients (67%, 95% CI 39.1 to 86.1%) using adjunctive diagnostic testing. VA stabilised or improved in 11 eyes (92%). Mean VA improved from 20/95 to 20/66 (p=0.055, paired t test). 25-Gauge TSV is safe and effective for obtaining vitreous specimens for the evaluation of IOL. The availability of expert ophthalmic pathological consultation, flow cytometry, cytokine evaluation and gene rearrangement studies were essential to the diagnosis.
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DOI：
10.1097/iae.0b013e31815ec2b3
发表时间：
2008-02-01
影响因子：
3.3
作者：
Hubschman, Jean Pierre;Gupta, Anurag;Schwartz, Steven D.
通讯作者：
Schwartz, Steven D.
影响因子：
13.7
作者：
Shen, DF;Zhuang, ZP;Chan, CC
通讯作者：
Chan, CC
DOI：
10.1097/00019606-199209000-00003
发表时间：
1992-09-01
期刊：
Diagnostic molecular pathology : the American journal of surgical pathology, part B
影响因子：
--
作者：
McCarthy, K P;Sloane, J P;Wiedemann, L M
通讯作者：
Wiedemann, L M
影响因子：
3.7
作者：
Chen, Eric
通讯作者：
Chen, Eric
影响因子：
13.7
作者：
Margolis, Ron;Brasil, Oswaldo F. M.;Sears, Jonathan E.
通讯作者：
Sears, Jonathan E.