Chemistry of the retinoid (visual) cycle.
Chemistry of the retinoid (visual) cycle.
复制标题
视网膜类似（视觉）周期的化学。
DOI：
10.1021/cr400107q
复制
发表时间：
2014-01-08
期刊：
影响因子：
62.1
通讯作者：
Palczewski, Krzysztof
中科院分区：
文献类型：
--
作者：
Kiser, Philip D.;Golczak, Marcin;Palczewski, Krzysztof
正如Wolf简要总结的那样，1缺乏维生素A(全反式视黄醇)被古埃及人认为是导致视网膜和角膜的视觉缺陷，可以通过吃肝脏来治愈。维生素A缺乏的症状之一是夜盲或夜视(源自希腊语νύκτ-nykt−Night和αλαός，alaos−blindness)，包括希波克拉底在内的古希腊人认为夜盲会影响视网膜。2 1913年，McCollum证明了“脂溶因子A”对于老鼠群体的生长是必不可少的(参考文献3)。治疗A因子缺乏症的方法包括肝脏或肝脏提取物，但后来在1930年，摩尔发现黄色素(胡萝卜素)是这种疗法的良好替代品。4一个重大突破发生在1931年，当时β，β-胡萝卜素和视黄醇(它的全反式异构体，现在称为维生素A)的化学结构由Karrer和他的同事确定。5但是，是沃德发现视黄醇衍生物构成了我们视觉的化学基础，6这一贡献后来得到1967年诺贝尔奖的认可。1950年−1960年，多种维生素A代谢
As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by ancient Egyptians as causing a visual deficiency involving the retina and cornea that could be cured by eating liver. One of the symptoms of vitamin A deficiency is night blindness or nyctalopia (from Greek νύκτ-, nykt− night; and αλαός, alaos− blindness), recognized by ancient Greeks, including Hippocrates, as affecting the retina. 2 In 1913 McCollum showed that “fat-soluble factor A” was essential for growth of a rat colony (reviewed in ref 3). The treatment of factor A-deficiency included liver or liver extracts, but later in 1930 Moore found that yellow pigment (carotene) was a good substitute for this therapy. 4 A major breakthrough occurred in 1931 when the chemical structures for β, β-carotene and retinol (its all-trans isomer now known as vitamin A) were determined by Karrer and colleagues. 5 But, it was Wald who discovered that retinol derivatives constitute the chemical basis of our vision, 6 a contribution subsequently recognized by a Nobel Prize award in 1967. In 1950− 1960, a variety of vitamin A metabolic
登录
查看更多内容
影响因子：
1.8
作者：
Baehr, Wolfgang;Frederick, Jeanne M.
通讯作者：
Frederick, Jeanne M.
影响因子：
6.5
作者：
Ables GP;Yang KJ;Vogel S;Hernandez-Ono A;Yu S;Yuen JJ;Birtles S;Buckett LK;Turnbull AV;Goldberg IJ;Blaner WS;Huang LS;Ginsberg HN
通讯作者：
Ginsberg HN
影响因子：
4.8
作者：
Ahn, J;Wong, JT;Molday, RS
通讯作者：
Molday, RS
影响因子：
4.8
作者：
Batten, ML;Imanishi, Y;Palczewski, K
通讯作者：
Palczewski, K
影响因子：
10.7
作者：
Albalat, Ricard
通讯作者：
Albalat, Ricard