Cellular signaling impacts upon GABAergic cortical interneuron development.

Cellular signaling impacts upon GABAergic cortical interneuron development.
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DOI:
10.3389/fnins.2023.1138653
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发表时间:
2023
影响因子:
4.3
通讯作者:
Vogt, Daniel
Vogt, Daniel
中科院分区:
医学2区
文献类型:
--
作者:
Pai, Emily Ling-Lin;Stafford, April M.;Vogt, Daniel

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皮质GABA能中间神经元的发育和成熟已被广泛研究,其中许多关注通过转录因子的核调控。虽然这些开创性的事件对于建立中间神经元发育里程碑至关重要,但最近对细胞信号级联的研究已经开始阐明细胞信号在发育过程中的一些潜在贡献。在这里,我们回顾了三个广泛的信号家族,mTOR,MAPK和Wnt/β-连环蛋白在皮质中间神经元发育的基础研究。值得注意的是,每个通路都含有调节广泛的中间神经元发育里程碑和特性的信号传导因子。总之,这些事件可能与转录机制和其他事件一起工作,以指导皮层中间神经元发育和成熟过程中出现的复杂多样性。
The development and maturation of cortical GABAergic interneurons has been extensively studied, with much focus on nuclear regulation via transcription factors. While these seminal events are critical for the establishment of interneuron developmental milestones, recent studies on cellular signaling cascades have begun to elucidate some potential contributions of cell signaling during development. Here, we review studies underlying three broad signaling families, mTOR, MAPK, and Wnt/beta-catenin in cortical interneuron development. Notably, each pathway harbors signaling factors that regulate a breadth of interneuron developmental milestones and properties. Together, these events may work in conjunction with transcriptional mechanisms and other events to direct the complex diversity that emerges during cortical interneuron development and maturation.
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